Lee Su Young, Bang Minji, Kim Kyung Ran, Lee Mi Kyung, Park Jin Young, Song Yun Young, Kang Jee In, Lee Eun, An Suk Kyoon
Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea; Department of Psychiatry, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul, South Korea.
Section of Affect and Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea; Department of Psychiatry, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea.
Schizophr Res. 2015 Jun;165(1):60-5. doi: 10.1016/j.schres.2015.03.026. Epub 2015 Apr 10.
This study aims to quantify facial emotion recognition abnormalities and their relation to neurocognitive dysfunction and schizotypy in individuals at ultra-high risk (UHR) for psychosis and patients with first-episode schizophrenia (FES).
Forty individuals at UHR for psychosis, 24 patients with FES and 46 normal controls performed a facial emotion recognition task that presented facial photographs encompassing all basic emotions. The perceptual aberration scale and revised social anhedonia scale were employed for self-reported assessment of schizotypy. An intellectual functioning (IQ) test and a broad battery of neurocognitive tests were conducted. Emotional task performance indexed by accuracy rate of specific emotion was compared among three groups. The correlation of accuracy rate with neurocognitive tests and schizotypy scales were analyzed within each clinical group.
A recognition deficit of facial emotions was present in both clinical groups, even after adjusting for IQ and gender as covariates. This emotional deficit showed few significant relationships with broad range of individual neurocognitive measures. Meanwhile, this deficit demonstrated significant relationships with schizotypy, especially perceptual aberration in each clinical group.
Facial emotion recognition deficit may not only be present in FES patients, but may already have evolved prior to the onset of overt psychotic symptoms. This emotion recognition deficit may be linked to a perceptual aberration and largely independent of broad range of neurocognitive dysfunction.
本研究旨在量化超高风险（UHR）精神病个体以及首发精神分裂症（FES）患者的面部情绪识别异常及其与神经认知功能障碍和精神分裂症样特征的关系。
40名UHR精神病个体、24名FES患者和46名正常对照者进行了一项面部情绪识别任务，该任务呈现了包含所有基本情绪的面部照片。采用感知偏差量表和修订的社交快感缺乏量表对精神分裂症样特征进行自我报告评估。进行了智力功能（IQ）测试和一系列广泛的神经认知测试。比较三组中以特定情绪准确率为指标的情绪任务表现。分析每个临床组内准确率与神经认知测试和精神分裂症样特征量表的相关性。
即使将IQ和性别作为协变量进行调整后，两个临床组均存在面部情绪识别缺陷。这种情绪缺陷与广泛的个体神经认知测量指标几乎没有显著关系。同时，这种缺陷与精神分裂症样特征显著相关，尤其是每个临床组中的感知偏差。
面部情绪识别缺陷不仅可能存在于FES患者中，而且可能在明显的精神病症状发作之前就已经出现。这种情绪识别缺陷可能与感知偏差有关，并且在很大程度上独立于广泛的神经认知功能障碍。
