Marvig Rasmus Lykke, Sommer Lea M, Jelsbak Lars, Molin Søren, Johansen Helle Krogh
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Future Microbiol. 2015;10(4):599-611. doi: 10.2217/fmb.15.3.
The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.
机会致病菌铜绿假单胞菌可导致囊性纤维化（CF）患者发生慢性气道感染，且与该疾病相关的发病率和死亡率直接相关。铜绿假单胞菌在CF患者中建立慢性感染的能力被认为归因于其庞大的基因库以及在基因层面适应宿主环境的能力。在此，我们综述了最近应用全基因组测序来理解铜绿假单胞菌群体基因组学、宿主内微进化与多样性、突变机制、基因适应性及传播事件的研究工作。最后，我们总结了在医学应用和实验室进化实验方面取得的进展。
