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Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells.

作者信息

Androutsopoulos Vasilis Pericles, Fragiadaki Irene, Tosca Androniki

机构信息

Laboratory of Experimental Dermatology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.

出版信息

Exp Dermatol. 2015 Aug;24(8):632-4. doi: 10.1111/exd.12721. Epub 2015 May 8.

DOI:10.1111/exd.12721
PMID:25865632
Abstract
摘要

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Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells.白藜芦醇类似物3,4,5,4'-四甲氧基二苯乙烯（DMU-212）在人黑色素瘤细胞中的抗有丝分裂活性需要ERK1/2的激活。
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Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol.白藜芦醇类似物反式3,4,5,4'-四甲氧基二苯乙烯（DMU-212）通过与白藜芦醇不同的机制介导抗肿瘤作用。
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Resveratrol analogue 3,4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells.白藜芦醇类似物 3,4,4',5-四甲氧基二苯乙烯抑制卵巢 SKOV-3 和 A-2780 癌细胞的生长，阻滞细胞周期并诱导细胞凋亡。
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