Guo Rui, Liong Emily C, So Kwok Fai, Fung Man-Lung, Tipoe George L
Departments of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Hepatobiliary Pancreat Dis Int. 2015 Apr;14(2):139-44. doi: 10.1016/s1499-3872(15)60355-1.
Non-alcoholic fatty liver disease (NAFLD) refers to any fatty liver disease that is not due to excessive use of alcohol. NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance. Aerobic exercise is shown to improve NAFLD. This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.
We searched articles in English on the role of aerobic exercise in NAFLD therapy in PubMed.
The mechanisms of chronic aerobic exercise in regulating the outcome of NAFLD include: (i) reducing intrahepatic fat content by down-regulating sterol regulatory element-binding protein-1c and up-regulating peroxisome proliferator-activated receptor gamma expression levels; (ii) decreasing hepatic oxidative stress through modulating the reactive oxygen species, and enhancing antioxidant enzymes such as catalase and glutathione peroxidase; (iii) ameliorating hepatic inflammation via the inhibition of pro-inflammatory mediators such as tumor necrosis factor-alpha and interleukin-1 beta; (iv) attenuating mitochondrial dependent apoptosis by reducing cytochrome C released from the mitochondria to the cytosol; and (v) inducing hepato-protective autophagy.
Aerobic exercise, via different mechanisms, significantly decreases the fat content of the liver and improves the outcomes of patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）指的是并非由过量饮酒导致的任何脂肪性肝病。NAFLD可能源于肝脏脂质代谢异常和胰岛素抵抗。有氧运动已被证明可改善NAFLD。本综述旨在评估有氧运动对NAFLD有益作用所涉及的分子机制。
我们在PubMed上检索了关于有氧运动在NAFLD治疗中作用的英文文章。
慢性有氧运动调节NAFLD结局的机制包括：（i）通过下调固醇调节元件结合蛋白-1c和上调过氧化物酶体增殖物激活受体γ的表达水平来降低肝内脂肪含量；（ii）通过调节活性氧来降低肝脏氧化应激，并增强过氧化氢酶和谷胱甘肽过氧化物酶等抗氧化酶；（iii）通过抑制肿瘤坏死因子-α和白细胞介素-1β等促炎介质来改善肝脏炎症；（iv）通过减少从线粒体释放到细胞质中的细胞色素C来减轻线粒体依赖性凋亡；以及（v）诱导肝脏保护性自噬。
有氧运动通过不同机制显著降低肝脏脂肪含量并改善NAFLD患者的病情。
