Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Section of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Genes (Basel). 2023 Sep 17;14(9):1811. doi: 10.3390/genes14091811.
The independent effect of exercise on liver histology in non-alcoholic fatty liver disease (NAFLD) remains unclear. As such, we conducted a systematic review and meta-analysis of the effect of exercise alone on histological endpoints in biopsy-proven NAFLD.
A systematic literature search was conducted to include controlled clinical trials investigating the effect of exercise alone on liver histology in biopsy-proven NAFLD. Meta-analysis was conducted for histological outcomes with available data from a minimum of three studies. Pooled estimates of the effect of exercise on histological endpoints were calculated using random-effects models.
We identified three controlled clinical trials that assessed the independent effect of exercise on histological outcomes in patients with biopsy-proven NAFLD. The studies consisted of 72 total participants, including 40 subjects in the exercise intervention and 32 individuals in the comparison group. Meta-analysis showed that exercise did not significantly improve Brunt grade, NAFLD activity score, and fibrosis in NAFLD.
Exercise alone may not lead to significant histopathological improvement in NAFLD. Future well-powered randomized controlled trials are needed to better characterize the impact of exercise on histological outcomes and clinical endpoints.
运动对非酒精性脂肪性肝病（NAFLD）肝组织学的独立影响尚不清楚。因此，我们对单独运动对活检证实的 NAFLD 组织学终点的影响进行了系统评价和荟萃分析。
进行了系统的文献检索，纳入了评估单独运动对活检证实的 NAFLD 患者肝组织学影响的对照临床试验。对于至少有三项研究提供了可用数据的组织学结果，使用随机效应模型进行了荟萃分析。
我们确定了三项对照临床试验，评估了运动对活检证实的 NAFLD 患者组织学结果的独立影响。这些研究共纳入了 72 名参与者，其中运动干预组有 40 名受试者，对照组有 32 名个体。荟萃分析显示，运动并不能显著改善 Brunt 分级、NAFLD 活动评分和 NAFLD 纤维化。
单独运动可能不会导致 NAFLD 的组织病理学显著改善。未来需要进行更大规模的随机对照试验，以更好地描述运动对组织学结果和临床终点的影响。
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