Ching Biyun, Chew Shit F, Ip Yuen K
Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore.
IUBMB Life. 2015 Feb;67(2):69-76. doi: 10.1002/iub.1360. Epub 2015 Apr 10.
Biosynthesis of ascorbate is known to occur in liver and/or kidney of some vertebrates; however, a recent study discovered the expression of l-gulono-γ-lactone oxidase, an enzyme essential for ascorbate synthesis, in the brain of the African lungfish, Protopterus annectens. This report provides an up-to-date review on ascorbate synthesis in fishes and the possible future directions of study in view of the discovery of the unusual site of ascorbate biosynthesis.
已知在一些脊椎动物的肝脏和/或肾脏中会发生抗坏血酸的生物合成；然而，最近一项研究发现，在非洲肺鱼（Protopterus annectens）的大脑中存在L-古洛糖酸-γ-内酯氧化酶（一种抗坏血酸合成所必需的酶）的表达。鉴于抗坏血酸生物合成的异常位点被发现，本报告提供了关于鱼类抗坏血酸合成的最新综述以及未来可能的研究方向。
