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免疫学中的外来因素:宽松边界的益处。

Immigrants in immunology: the benefits of lax borders.

作者信息

Stagaman Keaton, Martinez Emily S, Guillemin Karen

机构信息

Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.

Department of Computer and Information Science, University of Oregon, Eugene, OR 97403, USA.

出版信息

Trends Immunol. 2015 May;36(5):286-9. doi: 10.1016/j.it.2015.03.008. Epub 2015 Apr 9.

DOI:10.1016/j.it.2015.03.008
PMID:25866281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4420656/
Abstract

The field of immunology has a long history of illuminating fundamental biological processes of critical importance to human health. From an outsider's perspective, the questions are profoundly philosophical and the experimental approaches are elegantly precise. Yet immunology can also appear impenetrable. Here we recount the experience of two graduate students from the fields of ecology and computer science, who have immigrated into immunological terrain attracted by systems-level questions. We argue that such migrations enrich the field of immunology, and that cultural and institutional changes are needed to promote more interdisciplinary explorations.

摘要

免疫学领域在揭示对人类健康至关重要的基本生物学过程方面有着悠久的历史。从局外人的角度来看,这些问题极具哲学深度,而实验方法则精妙精准。然而,免疫学也可能显得难以理解。在此,我们讲述两位来自生态学和计算机科学领域的研究生的经历,他们受系统层面问题的吸引而踏入免疫学领域。我们认为,这样的跨界丰富了免疫学领域,并且需要文化和制度上的变革来推动更多的跨学科探索。

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1
Immigrants in immunology: the benefits of lax borders.免疫学中的外来因素:宽松边界的益处。
Trends Immunol. 2015 May;36(5):286-9. doi: 10.1016/j.it.2015.03.008. Epub 2015 Apr 9.
2
Computational and Systems Immunology: A Student's Perspective.计算与系统免疫学:学生视角。
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Systems Approaches towards Molecular Profiling of Human Immunity.系统方法在人类免疫的分子剖析中的应用。
Trends Immunol. 2016 Jan;37(1):53-67. doi: 10.1016/j.it.2015.11.006. Epub 2015 Dec 5.
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The JEM and the JCB: a synergistic partnership.《实验医学杂志》和《细胞生物学杂志》:一种协同合作关系。
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Advances in Computational Immunology.计算免疫学进展
J Immunol Res. 2015;2015:170920. doi: 10.1155/2015/170920. Epub 2015 Dec 30.
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Movies, measurement, and modeling: the three Ms of mechanistic immunology.电影、测量与建模:机制免疫学的三个M
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Ann N Y Acad Sci. 2011 Oct;1236:17-29. doi: 10.1111/j.1749-6632.2011.06251.x.

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Out of the Curricular Shadows: Revolutionizing Undergraduate Immunology Education.走出课程阴影:彻底革新本科免疫学教育
Front Immunol. 2019 Oct 15;10:2446. doi: 10.3389/fimmu.2019.02446. eCollection 2019.

本文引用的文献

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Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis.Foxp3(+) T 细胞调节免疫球蛋白 A 的选择,并促进负责免疫稳态的细菌物种的多样化。
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The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.体细胞高频突变对广泛中和HIV抗体PGT121家族中和及结合作用的影响。
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Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut.先天免疫和适应性免疫相互作用以抑制肠道微生物组鞭毛运动。
Cell Host Microbe. 2013 Nov 13;14(5):571-81. doi: 10.1016/j.chom.2013.10.009.
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The astonishing diversity of Ig classes and B cell repertoires in teleost fish.硬骨鱼类中 Ig 类别和 B 细胞库的惊人多样性。
Front Immunol. 2013 Feb 13;4:28. doi: 10.3389/fimmu.2013.00028. eCollection 2013.
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Gut immune maturation depends on colonization with a host-specific microbiota.肠道免疫成熟取决于与宿主特异性微生物组的定植。
Cell. 2012 Jun 22;149(7):1578-93. doi: 10.1016/j.cell.2012.04.037.
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Evidence for a core gut microbiota in the zebrafish.斑马鱼肠道核心微生物组的证据。
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High-throughput sequencing of the zebrafish antibody repertoire.斑马鱼抗体库的高通量测序
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Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.肠炎沙门氏菌鼠伤寒血清型利用炎症与肠道微生物群竞争。
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Adaptive immunity: care for the community.适应性免疫:守护群体。
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