Engels Gerwin Erik, van Oeveren Willem
HaemoScan BV, 9723 JC Groningen, Netherlands.
HaemoScan BV, 9723 JC Groningen, Netherlands ; Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Dis Markers. 2015;2015:472360. doi: 10.1155/2015/472360. Epub 2015 Mar 17.
Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of physiological changes, but comprehensive research is focused on determining biomarkers for early diagnosis of pulmonary dysfunction. Here we discuss the use of biomarkers of lung injury in cardiothoracic surgery and their ability to detect subtle pulmonary dysfunction in the perioperative period. Degranulation products of neutrophils are often used as biomarker since they have detrimental effects on the pulmonary tissue by themselves. However, these substances are not lung specific. Lung epithelium specific proteins offer more specificity and slowly find their way into clinical studies.
目前，肺功能障碍的诊断几乎完全基于一系列广泛的生理变化，但全面的研究集中在确定用于早期诊断肺功能障碍的生物标志物。在此，我们讨论心胸外科手术中肺损伤生物标志物的应用及其在围手术期检测细微肺功能障碍的能力。中性粒细胞的脱颗粒产物常被用作生物标志物，因为它们自身对肺组织有有害影响。然而，这些物质并非肺特异性的。肺上皮特异性蛋白具有更高的特异性，并逐渐进入临床研究。
