糖皮质激素和肿瘤坏死因子-α抑制剂对大动脉炎患者临床及分子参数的影响。
Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis.
作者信息
Serra Raffaele, Grande Raffaele, Buffone Gianluca, Scarcello Edoardo, Tripodi Fabio, Rende Pierandrea, Gallelli Luca, de Franciscis Stefano
机构信息
Department of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy.
Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.
出版信息
J Pharmacol Pharmacother. 2014 Jul;5(3):193-6. doi: 10.4103/0976-500X.136101.
Abstract
OBJECTIVE
To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA).
MATERIALS AND METHODS
In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated.
RESULTS
All treatments improved both symptoms and laboratory parameters without the development of side-effects.
CONCLUSIONS
It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.
摘要
目的
探讨糖皮质激素与肿瘤坏死因子-α抑制剂序贯治疗对大动脉炎（TA）患者的疗效。
材料与方法
对5例TA患者，评估先使用泼尼松治疗5 - 7个月，然后使用阿达木单抗（ADA）+甲氨蝶呤（MTX）或英夫利昔单抗+MTX，或仅使用ADA治疗12个月对临床和实验室检查结果的影响。
结果
所有治疗均改善了症状和实验室指标，且未出现副作用。
结论
推测基质金属蛋白酶-9和中性粒细胞明胶酶相关脂质运载蛋白可能是治疗反应的标志物。
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