Rasamiravaka Tsiry, Labtani Quentin, Duez Pierre, El Jaziri Mondher
Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
Department of Therapeutical Chemistry and Pharmacognosy, Université de Mons, Avenue Maistriau 19, Bâtiment Mendeleiev, 7000 Mons, Belgium.
Biomed Res Int. 2015;2015:759348. doi: 10.1155/2015/759348. Epub 2015 Mar 19.
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability. Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.
铜绿假单胞菌是一种引发急性和慢性感染的机会致病菌。除了对许多药物具有天然抗性外，它形成生物膜（一种复杂的生物系统）的能力使得免疫防御系统和抗菌疗法无法有效清除感染。本报告的目的是概述：（i）铜绿假单胞菌生物膜生活周期；（ii）与铜绿假单胞菌生物膜形成调控相关的主要关键因素，包括群体感应系统、GacS/GacA和RetS/LadS双组分系统以及环二鸟苷酸依赖性多糖生物合成；（iii）最后介绍已报道的天然和合成产物，这些产物可干扰铜绿假单胞菌生物膜形成的控制机制，且不直接影响细菌活力。结语着重探讨将生物膜生活方式作为根除铜绿假单胞菌引起的耐药感染靶点的前景。
