Wang Dong V, Yau Hau-Jie, Broker Carl J, Tsou Jen-Hui, Bonci Antonello, Ikemoto Satoshi
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
Nat Neurosci. 2015 May;18(5):728-35. doi: 10.1038/nn.3998. Epub 2015 Apr 13.
Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal ripple activity and memory consolidation. We performed in vivo simultaneous recording in the MnR and hippocampus of mice and found that, when a group of MnR neurons was active, ripples were absent. Consistently, optogenetic stimulation of MnR neurons suppressed ripple activity and inhibition of these neurons increased ripple activity. Notably, using a fear conditioning procedure, we found that photostimulation of MnR neurons interfered with memory consolidation. Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.
海马体中与尖锐波相关的场振荡（约200赫兹），即所谓的涟漪，被认为对显性记忆的巩固很重要。关于涟漪如何受其他脑区调节，人们知之甚少。我们发现中缝正中区域（MnR）对调节海马体涟漪活动和记忆巩固很重要。我们在小鼠的MnR和海马体中进行了体内同步记录，发现当一组MnR神经元活跃时，涟漪就会消失。同样，对MnR神经元进行光遗传学刺激会抑制涟漪活动，而抑制这些神经元则会增加涟漪活动。值得注意的是，通过恐惧条件反射程序，我们发现对MnR神经元进行光刺激会干扰记忆巩固。我们的结果证明了MnR在调节涟漪和记忆巩固中的关键作用。
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