CNRS-Collège de France, LPPA, UMR7152, 11 place Marcelin Berthelot, 75005 Paris, France.
Curr Opin Neurobiol. 2011 Jun;21(3):452-9. doi: 10.1016/j.conb.2011.02.005. Epub 2011 Mar 1.
During slow wave sleep and quiet wakefulness, the hippocampus generates high frequency field oscillations (ripples) during which pyramidal neurons replay previous waking activity in a temporally compressed manner. As a result, reactivated firing patterns occur within shorter time windows propitious for synaptic plasticity within the hippocampal network and in downstream neocortical structures. This is consistent with the long-held view that ripples participate in strengthening and reorganizing memory traces, possibly by mediating information transfer to neocortical areas. Recent studies have confirmed that ripples and associated neuronal reactivations play a causal role in memory consolidation during sleep and rest. However, further research will be necessary to better understand the neurophysiological mechanisms of memory consolidation, in particular the selection of reactivated assemblies, and the functional specificity of awake ripples.
在慢波睡眠和安静觉醒期间，海马体在高频场振荡（涟漪）期间产生尖峰神经元以时间压缩方式再现先前的觉醒活动。结果，重新激活的发射模式出现在更短的时间窗口内，有利于海马网络和下游新皮层结构中的突触可塑性。这与长期以来的观点一致，即涟漪参与增强和重组记忆痕迹，可能通过介导信息传递到新皮层区域。最近的研究证实，涟漪和相关神经元的重新激活在睡眠和休息期间的记忆巩固中起因果作用。然而，需要进一步的研究来更好地理解记忆巩固的神经生理机制，特别是重新激活的集合的选择，以及清醒涟漪的功能特异性。
