Navarro S D, Mauro M O, Pesarini J R, Ogo F M, Oliveira R J
Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brasil.
Genet Mol Res. 2015 Mar 6;14(1):1679-91. doi: 10.4238/2015.March.6.14.
Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated. Animals were treated with 1,2-dimethylhydrazine and their diet was supplemented with 10% green banana flour according to the following resistant starch protocols: pretreatment, simultaneous treatment, post-treatment, and pre + continuous treatment. The results demonstrated that resistant starch is not genotoxic, mutagenic, or carcinogenic. The results suggest that resistant starch acts through desmutagenesis and bio-antimutagenesis, as well as by reducing aberrant crypt foci, thereby improving disease prognosis. These findings imply that green banana flour has therapeutic properties that should be explored for human dietary applications.
抗性淀粉由淀粉及其降解产物形成，在肠道中不被消化或吸收；因此，它被归类为一种膳食纤维。由于膳食纤维的摄入与预防DNA损伤和癌症有关，因此对绿香蕉粉中的抗性淀粉潜在的抗遗传毒性、抗诱变和抗癌能力进行了评估。用1,2 - 二甲基肼处理动物，并根据以下抗性淀粉方案在其饮食中添加10%的绿香蕉粉：预处理、同时处理、后处理以及预处理 + 持续处理。结果表明，抗性淀粉没有遗传毒性、诱变或致癌性。结果表明，抗性淀粉通过去诱变和生物抗诱变作用，以及减少异常隐窝病灶发挥作用，从而改善疾病预后。这些发现意味着绿香蕉粉具有治疗特性，应在人类饮食应用中加以探索。
