Mohd Suan Mohd Azri, Tan Wei Leong, Soelar Shahrul Aiman, Ismail Ibtisam, Abu Hassan Muhammad Radzi
Clinical Research Center, Sultanah Bahiyah Hospital, Kedah, Malaysia.
Epidemiol Health. 2015 Mar 30;37:e2015017. doi: 10.4178/epih/e2015017. eCollection 2015.
The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.
Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.
Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).
The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.
本研究旨在评估肠梗阻与结直肠癌预后之间的关系。
从国家结直肠癌登记处提取并分析了4501例结直肠癌患者的数据。采用Kaplan-Meier法进行生存分析。采用对数秩检验比较肠梗阻患者和非肠梗阻患者的生存率。p值<0.05被认为具有统计学意义。采用简单Cox比例风险回归分析估计结直肠癌死亡的粗风险比。
超过13%的患者报告有肠梗阻。肠梗阻患者（n = 593）治疗后的3年生存率为48.3%（95%置信区间[CI]，43.9至52.8），非肠梗阻患者（n = 3908）为54.9%（95% CI，53.1至56.6）。肠梗阻患者的5年生存率为37.3%（95% CI，31.9至42.8），低于非肠梗阻患者（45.6%；95% CI，43.5至47.7）。在对其他预后变量的风险比进行调整后，肠梗阻与结直肠癌患者的生存率具有统计学意义的负相关，调整后的风险比为1.22（p = 0.008）。
肠梗阻的存在与结直肠癌患者较低的生存率相关。
