Auvinen Anssi, Kivelä Tero, Heinävaara Sirpa, Mrena Samy
1.STUK - Radiation and Nuclear Safety Authority, Department of Environmental Surveillance, Laippatie 4, Helsinki, Finland; 2.University of Tampere, School of Health Sciences, Medisiinarinkatu 3, Tampere, Finland;
3.Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4C, Helsinki, Finland; 4.University of Helsinki, School of Medicine, Tukholmankatu 8B, Helsinki, Finland.
Ann Occup Hyg. 2015 Aug;59(7):945-8. doi: 10.1093/annhyg/mev022. Epub 2015 Apr 13.
We compared the frequency of lens opacities among physicians with and without occupational exposure to ionizing radiation, and estimated dose-response between cumulative dose and opacities. We conducted ophthalmologic examinations of 21 physicians with occupational exposure to radiation and 16 unexposed physicians. Information on cumulative radiation doses (mean 111 mSv) was based on dosimeter readings recorded in a national database on occupational exposures. Lens changes were evaluated using the Lens Opacities Classification System II, with an emphasis on posterior subcapsular (PSC) and cortical changes. Among the exposed physicians, the prevalences of cortical and PSC changes were both 11% (3/21), and the corresponding frequencies in the unexposed group were 44% (n = 7) and 6% (n = 1). For dose-response analysis, the data were pooled with 29 exposed physicians from our previous study. No association of either type of lens changes with cumulative recorded dose was observed. Our findings do not indicate an increased frequency of lens opacities in physicians with occupational exposure to ionizing radiation. However, the subjects in this study have received relatively low doses and therefore the results do not exclude small increases in lens opacities or contradict the studies reporting increases among interventional cardiologists with materially higher cumulative doses.
我们比较了有职业性电离辐射暴露和无职业性电离辐射暴露的医生晶状体混浊的频率，并估计了累积剂量与混浊之间的剂量反应关系。我们对21名有职业性辐射暴露的医生和16名无辐射暴露的医生进行了眼科检查。累积辐射剂量信息（平均111毫希沃特）基于国家职业暴露数据库中记录的剂量计读数。使用晶状体混浊分类系统II评估晶状体变化，重点关注后囊下（PSC）和皮质变化。在有辐射暴露的医生中，皮质和PSC变化的患病率均为11%（3/21），在无辐射暴露组中相应的频率分别为44%（n = 7）和6%（n = 1）。为了进行剂量反应分析，我们将数据与之前研究中的29名有辐射暴露的医生的数据合并在一起。未观察到任何一种类型的晶状体变化与累积记录剂量之间存在关联。我们的研究结果并未表明有职业性电离辐射暴露的医生晶状体混浊频率增加。然而，本研究中的受试者接受的剂量相对较低，因此结果并不排除晶状体混浊有小幅增加的可能性，也不与那些报告累积剂量高得多的介入心脏病专家晶状体混浊增加的研究相矛盾。
