Boccia Maddalena, Acierno Mauro, Piccardi Laura
Department of Psychology, "Sapienza" University of Rome, Italy.
Neuropsychology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
J Alzheimers Dis. 2015;46(4):963-70. doi: 10.3233/JAD-142955.
Depression and cognitive impairment are both common disorders in elderly people and frequently occur together. Due to the presence of a common set of behavioral and cognitive symptoms, differential diagnosis may become arduous. Neuroimaging may offer a good tool during diagnosis. We performed a coordinate-based meta-analysis to compare gray matter changes in Alzheimer's disease (AD) and late-life depression (LLD). AD and LLD led to brain atrophy in networks only partially overlapping. Both conditions are linked to a reduction of the bilateral hippocampal volume, but AD is correlated with great atrophy in the left anterior hippocampus and bilateral posterior cingulate cortex, while LLD is correlated with great atrophy in the precuneus, superior frontal gyrus, and ventromedial frontal cortex. Present results shed some light on neural underpinnings of AD and LLD and provide new useful evidence for differential diagnosis.
抑郁症和认知障碍在老年人中都是常见疾病，且经常同时出现。由于存在一系列共同的行为和认知症状，鉴别诊断可能会变得困难。神经影像学检查可能是诊断过程中的一个好工具。我们进行了一项基于坐标的荟萃分析，以比较阿尔茨海默病（AD）和老年期抑郁症（LLD）中的灰质变化。AD和LLD导致的脑萎缩仅部分重叠于某些脑网络。这两种情况都与双侧海马体积减小有关，但AD与左侧前海马和双侧后扣带回皮质的严重萎缩相关，而LLD与楔前叶、额上回和额内侧腹侧皮质的严重萎缩相关。目前的研究结果为AD和LLD的神经基础提供了一些线索，并为鉴别诊断提供了新的有用证据。
