Pievani Michela, Pini Lorenzo, Ferrari Clarissa, Pizzini Francesca B, Boscolo Galazzo Ilaria, Cobelli Chiara, Cotelli Maria, Manenti Rosa, Frisoni Giovanni B
Laboratory Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
J Alzheimers Dis. 2017;57(3):825-843. doi: 10.3233/JAD-161105.
The accurate choice of the site of non-invasive brain stimulation (NIBS) is an important factor in trial design.
Based on the observation that Alzheimer's disease (AD) and behavioral frontotemporal dementia (bvFTD) affect specific large-scale networks, i.e., the default mode network (DMN) and the salience network (SN), respectively, we aimed to identify population-average coordinates of these networks that could be used as potential targets in NIBS trials aiming to modulate these circuits.
A systematic literature search of resting-state functional MRI studies reporting DMN and SN stereotactic coordinates was performed according to PRISMA guidelines. Coordinate-based meta-analyses were conducted to identify consistent nodes of the DMN and SN using GingerALE BrainMap software and the activation likelihood estimation method.
DMN coordinates mapped primarily to mesial areas (posterior cingulate cortex/precuneus [Brodmann Area - BA 23/31] and medial prefrontal cortex [BA 9/10/32]). More superficial areas mapped to the bilateral parietal (angular gyrus [BA 39]), temporal (middle gyrus [BA 21]) and dorsolateral prefrontal (superior gyrus [BA 8]) cortex. SN coordinates mapped primarily to mesial and deep frontal areas (anterior insula, anterior cingulate cortex [BA 24/32]), but more superficial areas mapped to the bilateral parietal (supramarginal gyrus [BA 40]) and the right dorsolateral prefrontal (middle gyrus [BA 9/10]) cortex.
NIBS should target the bilateral angular, the middle temporal cortex, or superior frontal gyri in AD for DMN modulation, and the right middle frontal or supramarginal gyri in bvFTD for SN modulation.
非侵入性脑刺激（NIBS）部位的准确选择是试验设计中的一个重要因素。
基于观察到阿尔茨海默病（AD）和行为性额颞叶痴呆（bvFTD）分别影响特定的大规模网络，即默认模式网络（DMN）和突显网络（SN），我们旨在确定这些网络的群体平均坐标，可将其用作旨在调节这些回路的NIBS试验中的潜在靶点。
根据PRISMA指南，对报告DMN和SN立体定向坐标的静息态功能磁共振成像研究进行系统的文献检索。使用GingerALE BrainMap软件和激活似然估计方法进行基于坐标的荟萃分析，以确定DMN和SN的一致节点。
DMN坐标主要映射到内侧区域（后扣带回皮质/楔前叶[布罗德曼区 - BA 23/31]和内侧前额叶皮质[BA 9/10/32]）。更浅表的区域映射到双侧顶叶（角回[BA 39]）、颞叶（颞中回[BA 21]）和背外侧前额叶（额上回[BA 8]）皮质。SN坐标主要映射到内侧和深部额叶区域（前岛叶、前扣带回皮质[BA 24/32]），但更浅表的区域映射到双侧顶叶（缘上回[BA 40]）和右侧背外侧前额叶（颞中回[BA 9/10]）皮质。
在AD中，NIBS应靶向双侧角回、颞中皮质或额上回以调节DMN，在bvFTD中应靶向右侧额中回或缘上回以调节SN。
