Zhang Peng, Cao Hong-Yi, Bai Lin-Lin, Li Wei-Nan, Wang Yuan, Chen Song-Yan, Zhang Li, Yang Lian-He, Xu Hong-Tao, Wang En-Hua
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, 110001, China.
Department of Stomatology, The 463 Hospital of Chinese PLA, Shenyang, 110042, China.
Tumour Biol. 2015 Sep;36(9):7061-7. doi: 10.1007/s13277-015-3423-1. Epub 2015 Apr 14.
Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers. The objective of this study was to examine the expression of TC1 and investigate the associations among TC1, β-catenin, Chibby, cyclin D1, and the clinicopathological factors of oral tongue squamous cell carcinomas (OTSCCs). The expressions of TC1, β-catenin, Chibby, and cyclin D1 were examined in 109 cases of OTSCCs using immunohistochemistry. The expression of TC1 was observed in all cases of OTSCCs but was negative or weak in normal squamous epithelial tissues of tongue. The high expression of TC1 was correlated with the advanced TNM stage (P = 0.042), the abnormal expression of β-catenin (correlation coefficient = 0.314, P = 0.001) and the expression of cyclin D1 (correlation coefficient = 0.274, P = 0.006) in OTSCCs. But we did not find any associations between TC1 and Chibby. The abnormal expression of β-catenin was correlated with the poor differentiation (P = 0.035), advanced TNM stage (P = 0.048) and the expression of cyclin D1 (correlation coefficient = 0.422, P < 0.001). In conclusion, the high expression of TC1 was common in OTSCCs and correlated with the expression of β-catenin and cyclin D1 and the progression of OTSCCs. The high expression level of TC1 might promote the progression of OTSCCs by enhancing the activity of Wnt signaling pathway.
甲状腺癌1（TC1，C8orf4）在许多信号通路中发挥重要作用，如Wnt/β-连环蛋白信号通路，并参与多种癌症的发生发展。本研究旨在检测TC1的表达，并探讨TC1、β-连环蛋白、Chibby、细胞周期蛋白D1与口腔舌鳞状细胞癌（OTSCC）临床病理因素之间的关系。采用免疫组织化学方法检测109例OTSCC中TC1、β-连环蛋白、Chibby和细胞周期蛋白D1的表达。在所有OTSCC病例中均观察到TC1的表达，但在舌正常鳞状上皮组织中呈阴性或弱阳性。TC1的高表达与OTSCC的TNM分期进展（P = 0.042）、β-连环蛋白的异常表达（相关系数 = 0.314，P = 0.001）和细胞周期蛋白D1的表达（相关系数 = 0.274，P = 0.006）相关。但未发现TC1与Chibby之间存在任何关联。β-连环蛋白的异常表达与低分化（P = 0.035）、TNM分期进展（P = 0.048）和细胞周期蛋白D1的表达（相关系数 = 0.422，P < 0.001）相关。总之，TC1的高表达在OTSCC中常见，且与β-连环蛋白和细胞周期蛋白D1的表达及OTSCC的进展相关。TC1的高表达水平可能通过增强Wnt信号通路的活性促进OTSCC的进展。
