Sippel Lauren M, Jones Rachel E, Bordieri Michael J, Dixon Laura J, May Anna C, Malkin Mallory L, Schumacher Julie A, Coffey Scott F
University of Mississippi Medical Center, 2500 North State St., Jackson, MS 39216, USA ; G.V. (Sonny) Montgomery VA Medical Center, 1500 E Woodrow Wilson Ave, Jackson, MS 39216, USA.
University of Mississippi Medical Center, 2500 North State St., Jackson, MS 39216, USA.
Cognit Ther Res. 2015 Apr;39(2):245-252. doi: 10.1007/s10608-014-9648-2.
Individuals with posttraumatic stress disorder (PTSD) exhibit deficits in cognitive and emotional processes. PTSD severity is positively associated with anxiety sensitivity (AS) and difficulties in emotion regulation, and difficulties in emotion regulation mediate the relation between AS and PTSD. However, previous research has not examined the interactive nature of these variables. Associations between PTSD, AS, and difficulties in emotion regulation were examined in patients with PTSD in a residential substance treatment program (N = 120). Conditional process analyses indicated an interactive effect of difficulties in emotion regulation and AS for predicting PTSD symptom severity. For individuals high in emotion regulation difficulties, PTSD symptom severity was high regardless of level of AS; conversely, for individuals high in AS, increased PTSD severity was observed regardless of level of emotion regulation difficulties. Results suggest directions for future research, including targeting patient specific cognitive-affective processes to enhance PTSD treatment response among substance dependent individuals.
患有创伤后应激障碍（PTSD）的个体在认知和情感过程中表现出缺陷。PTSD的严重程度与焦虑敏感性（AS）以及情绪调节困难呈正相关，并且情绪调节困难在AS与PTSD之间的关系中起中介作用。然而，先前的研究尚未考察这些变量的交互性质。在一个住院药物治疗项目中，对120名PTSD患者的PTSD、AS和情绪调节困难之间的关联进行了研究。条件过程分析表明，情绪调节困难和AS对预测PTSD症状严重程度具有交互作用。对于情绪调节困难程度高的个体，无论AS水平如何，PTSD症状严重程度都很高；相反，对于AS水平高的个体，无论情绪调节困难程度如何，都观察到PTSD严重程度增加。研究结果为未来的研究指明了方向，包括针对患者特定的认知-情感过程，以提高药物依赖个体对PTSD治疗的反应。
