Sharafi Ahmad, Pour Hosseini Hamid Reza, Jalali Arash, Salarifar Mojtaba, Nematipour Ebrahim, Shojanasab Mohsen, Aghajani Hassan, Amirzadegan Alireza, Nozari Younes, Alidoosti Mohamad, Zeinali Alimohammad Haji, Kassaian Seyed Ebrahim
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
J Tehran Heart Cent. 2014;9(3):115-9. Epub 2014 Jul 3.
Controversy persists over the potential benefits/harms of opium consumption in coronary heart disease. This study investigated the association between 12 months' major adverse cardiac events (MACE) and pre-procedural opium consumption among patients undergoing percutaneous coronary intervention (PCI).
Retrospectively, 1545 consecutive men who underwent PCI between 21(st) June 2009 and 20th June 2010 at Tehran Heart Center and were registered in the PCI Databank were entered into this cohort study. The occurrence of MACE, defined as cardiac death, non-fatal myocardial infarction, and need for target vessel revascularization (TVR) or target lesion revascularization (TLR), was compared between two groups of opium consumers and non-consumers in 350 (22.7%) patients.
Sixty-four (0.86%) patients expired within 12 months. After adjustment for potential confounders, analysis revealed that opium consumption had no significant relationship with 12 months' MACE [11(3.1%) vs. 53(4.4%); p value = 0.286, among opium users vs. non users, respectively].Furthermore, the different components of MACE, including target vessel revascularization, target lesion revascularization, coronary artery bypass graft, and non-fatal myocardial infarction, were not significantly related to opium use.
Pre-procedural opium usage in patients undergoing PCI was not associated with 12 months' MACE.
关于冠心病患者使用鸦片的潜在益处/危害一直存在争议。本研究调查了接受经皮冠状动脉介入治疗（PCI）的患者术前使用鸦片与12个月主要不良心脏事件（MACE）之间的关联。
本队列研究回顾性纳入了2009年6月21日至2010年6月20日在德黑兰心脏中心接受PCI并登记在PCI数据库中的1545例连续男性患者。在350例（22.7%）患者中，比较了使用鸦片组和未使用鸦片组之间MACE（定义为心源性死亡、非致命性心肌梗死以及需要进行靶血管血运重建术（TVR）或靶病变血运重建术（TLR））的发生情况。
64例（0.86%）患者在12个月内死亡。在对潜在混杂因素进行校正后，分析显示使用鸦片与12个月的MACE无显著相关性[使用鸦片者与未使用者中分别为11例（3.1%）对53例（4.4%）；p值=0.286]。此外，MACE的不同组成部分，包括靶血管血运重建、靶病变血运重建、冠状动脉搭桥术和非致命性心肌梗死，均与使用鸦片无显著相关性。
接受PCI的患者术前使用鸦片与12个月的MACE无关。
