Perge Pál, Nagy Zoltán, Igaz Ivan, Igaz Peter
Biomol Concepts. 2015 Apr;6(2):149-55. doi: 10.1515/bmc-2015-0002.
MicroRNAs are short non-coding RNA molecules encoded by distinct genes involved in the posttranscriptional regulation of gene expression. Forming part of the epigenetic machinery, microRNAs are involved in several aspects of tumorigenesis. Deregulation of microRNA expression is a common feature of tumors. Overexpressed oncogenic and underexpressed tumor suppressor microRNAs have been described in many different tumors. MicroRNAs are released from tumors that might affect other cells within and outside the tumor. Circulating microRNAs might also be involved in a tumor surveillance mechanism. In this short overview, some important aspects of microRNA in tumors are discussed.
微小RNA是由不同基因编码的短链非编码RNA分子，参与基因表达的转录后调控。作为表观遗传机制的一部分，微小RNA参与肿瘤发生的多个方面。微小RNA表达失调是肿瘤的一个常见特征。在许多不同肿瘤中都已发现致癌性微小RNA过表达和肿瘤抑制性微小RNA表达不足的情况。微小RNA从肿瘤中释放出来，可能会影响肿瘤内外的其他细胞。循环中的微小RNA也可能参与肿瘤监测机制。在本简短综述中，将讨论微小RNA在肿瘤中的一些重要方面。
