National Collaborating Centre for Cancer, Wales, United Kingdom.
Department of Respiratory Medicine, Nottingham University Hospitals National Health Service Trust, Nottingham City Hospital, United Kingdom.
JAMA. 2015 Apr 14;313(14):1465-6. doi: 10.1001/jama.2015.2365.
What is the sensitivity and specificity of 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging for detecting mediastinal lymph node involvement in patients with potentially resectable non-small cell lung cancer (NSCLC)?
Sensitivity and specificity of FDG-PET/CT imaging ranged from 0.77 to 0.81 for sensitivity and 0.79 to 0.90 for specificity, and were related to the brand of scanner, NSCLC subtype, FDG dose, and country of study origin. These sensitivities and specificities are not sufficiently accurate to warrant reliance on FDG-PET/CT scanning alone to make decisions about surgery as a single option for patients with potentially resectable NSCLC. Instead FDG-PET/CT imaging should be used to determine whether the next step should be biopsy (endobronchial ultrasound-guided biopsy or mediastinoscopy) or surgical resection.
18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）成像在检测潜在可切除性非小细胞肺癌（NSCLC）患者纵隔淋巴结受累中的灵敏度和特异性如何？
FDG-PET/CT 成像的灵敏度范围为 0.77 至 0.81，特异性范围为 0.79 至 0.90，与扫描仪品牌、NSCLC 亚型、FDG 剂量和研究来源国家有关。这些灵敏度和特异性不够准确，不能仅凭 FDG-PET/CT 扫描就决定对潜在可切除性 NSCLC 患者单独采用手术作为单一选择。相反，FDG-PET/CT 成像应用于确定下一步是进行活检（支气管内超声引导活检或纵隔镜检查）还是手术切除。
