Jorgensen C J, Dreyfus F, Vaixeler J, Guyomard S, Massiot C, Belanger C, Brunet F, Giraud T, Dupuis-Camay P
Service d'Hématologie, Hôpital Cochin, Paris, France.
Nouv Rev Fr Hematol (1978). 1989;31(5):327-8.
We tested the efficiency of a nasal spray of Amphotericin B (AmB) in leukemic patients, in an attempt to prevent pulmonary Aspergillosis. From January to July, 8 cases of invasive Aspergillosis (IA) in 19 new leukemic patients were identified. Between July and September 15 patients were treated by prophylactic nasal spray of AmB (daily dose 5 mg). Compliance was excellent, but nevertheless typical IA developed in 5 patients. We conclude that at the dosage used prophylactic administration of nasal spray of (AmB) does not prevent IA.
我们测试了两性霉素B（AmB）鼻喷雾剂对白血病患者预防肺曲霉病的效果。从1月至7月，在19名新诊断的白血病患者中发现了8例侵袭性曲霉病（IA）。7月至9月期间，15名患者接受了AmB预防性鼻喷雾治疗（每日剂量5毫克）。依从性良好，但仍有5名患者发生了典型的IA。我们得出结论，以所用剂量进行AmB鼻喷雾预防性给药并不能预防IA。
