Trigg M E, Morgan D, Burns T L, Kook H, Rumelhart S L, Holida M D, Giller R H
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
Bone Marrow Transplant. 1997 Jan;19(1):43-7. doi: 10.1038/sj.bmt.1700618.
Aspergillus infections in the pediatric bone marrow transplant (BMT) patients are usually fatal. We began the use of a prophylactic nasal spray of amphotericin in 1990. This nasal spray was provided in addition to low-dose intravenous amphotericin. During the time of this study, the number of fatal cases of aspergillus in the pediatric BMT population was reduced significantly from 13.8% to 1.8% (P < 0.0025) thereby suggesting that the use of nasal amphotericin in this population helps to prevent fatal aspergillus infections. The lack of significant side-effects and the ease of administration make this a very helpful preventive measure in the supportive care of pediatric bone marrow transplant patients.
