雾化两性霉素B预防侵袭性肺曲霉病
Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis.
作者信息
Beyer J, Barzen G, Risse G, Weyer C, Miksits K, Dullenkopf K, Huhn D, Siegert W
机构信息
Abteilung Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Universitätsklinikum Rudolf Virchow, Freien Universität Berlin, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1993 Jun;37(6):1367-9. doi: 10.1128/AAC.37.6.1367.
The pharmacokinetics and applicability of aerosol amphotericin B administrations were studied in 40 neutropenic patients and 4 healthy volunteers. Particle size was measured and pulmonary deposition was demonstrated by radioisotope studies. Inhalations were easy to administer and were well tolerated, with minimal systemic absorption of the drug.
在40例中性粒细胞减少患者和4名健康志愿者中研究了雾化两性霉素B给药的药代动力学和适用性。通过放射性同位素研究测量了粒径并证实了肺部沉积。吸入给药易于实施且耐受性良好，药物的全身吸收极少。
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