Brown Matthew R D, Ramirez Juan D
aThe Royal Marsden Hospital, London, UK bThe Institute of Cancer Research, Sutton, Surrey, UK cNuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford, Headington, Oxford, UK.
Curr Opin Support Palliat Care. 2015 Jun;9(2):103-11. doi: 10.1097/SPC.0000000000000140.
The current review provides a summary of recent advances in our understanding of the neuroimmune interactions which influence the development of pain associated with cancer.
Common signalling pathways, mediators and immune cell types are involved in the generation of pain as a result of both cancer and its treatment. Distinct alterations in central and peripheral neuronal function occur in multiple forms of cancer pain. Other more unusual neuroimmune processes such as graft-versus-host disease may cause cancer pain.
Identification of the cellular processes which underlie the generation of cancer pain provide potential novel targets for drug development and may eventually lead to improved pain management for cancer patients.
本综述总结了我们对影响癌症相关疼痛发生的神经免疫相互作用的最新认识进展。
癌症及其治疗导致疼痛产生的过程中涉及常见的信号通路、介质和免疫细胞类型。多种形式的癌症疼痛会导致中枢和外周神经元功能发生明显改变。其他更不常见的神经免疫过程，如移植物抗宿主病，也可能导致癌症疼痛。
确定癌症疼痛产生的细胞过程为药物开发提供了潜在的新靶点，并最终可能改善癌症患者的疼痛管理。
