用于在肿瘤pH值下增强细胞摄取的酰基磺酰胺功能化两性离子金纳米颗粒。
Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.
作者信息
Mizuhara Tsukasa, Saha Krishnendu, Moyano Daniel F, Kim Chang Soo, Yan Bo, Kim Young-Kwan, Rotello Vincent M
机构信息
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan).
出版信息
Angew Chem Int Ed Engl. 2015 May 26;54(22):6567-70. doi: 10.1002/anie.201411615. Epub 2015 Apr 14.
Abstract
A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
摘要
本文报道了一种具有pH响应性烷氧基苯基酰基磺酰胺配体的纳米颗粒设计。由于配体结构，这种纳米颗粒在pH 7.4时呈中性，在肿瘤pH值（<6.5）时带正电荷。在这个pH范围内，颗粒的摄取和细胞毒性增加。这种pH控制的摄取和毒性使这种颗粒成为肿瘤选择性治疗的一个有前途的工具。
相似文献
1
Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.用于在肿瘤pH值下增强细胞摄取的酰基磺酰胺功能化两性离子金纳米颗粒。
Angew Chem Int Ed Engl. 2015 May 26;54(22):6567-70. doi: 10.1002/anie.201411615. Epub 2015 Apr 14.
2
Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells.将疏水性药物包裹于纳米颗粒单层中并高效释放至癌细胞内。
J Am Chem Soc. 2009 Feb 4;131(4):1360-1. doi: 10.1021/ja808137c.
3
Tc-Labeled Polyethylenimine-Entrapped Gold Nanoparticles with pH-Responsive Charge Conversion Property for Enhanced Dual Mode SPECT/CT Imaging of Cancer Cells.Tc 标记的具有 pH 响应电荷转换特性的聚乙烯亚胺包埋金纳米粒子用于增强癌细胞的双模式 SPECT/CT 成像。
Langmuir. 2019 Oct 15;35(41):13405-13412. doi: 10.1021/acs.langmuir.9b02617. Epub 2019 Oct 3.
4
Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis.两性离子功能化树枝状大分子包裹的金纳米粒子用于血清增强的基因递送来抑制癌细胞转移。
Acta Biomater. 2019 Nov;99:320-329. doi: 10.1016/j.actbio.2019.09.005. Epub 2019 Sep 9.
5
Recovery and redispersion of gold nanoparticles using the self-assembly of a pH sensitive zwitterionic amphiphile.利用pH敏感两性离子两亲物的自组装实现金纳米颗粒的回收与再分散
Chem Commun (Camb). 2014 Nov 4;50(85):12933-6. doi: 10.1039/c4cc04935g.
6
Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles.多功能紧凑型两性离子配体用于制备稳健的生物相容性半导体量子点和金纳米粒子。
J Am Chem Soc. 2011 Jun 22;133(24):9480-96. doi: 10.1021/ja201919s. Epub 2011 May 25.
7
Zwitterionic phosphorylcholine as a better ligand for gold nanorods cell uptake and selective photothermal ablation of cancer cells.两性离子型磷酸胆碱作为金纳米棒更好的配体用于提高细胞摄取效率并选择性光热消融癌细胞。
Chem Commun (Camb). 2010 Mar 7;46(9):1479-81. doi: 10.1039/b915125g. Epub 2010 Jan 19.
8
Intracellular Enzyme-Triggered Assembly of Amino Acid-Modified Gold Nanoparticles for Accurate Cancer Therapy with Multimode.细胞内酶触发的氨基酸修饰金纳米粒子的组装用于具有多种模式的精确癌症治疗。
ACS Appl Mater Interfaces. 2019 Aug 14;11(32):28621-28630. doi: 10.1021/acsami.9b05943. Epub 2019 Jul 31.
9
Enhanced retention and cellular uptake of nanoparticles in tumors by controlling their aggregation behavior.通过控制纳米粒子的聚集行为来增强其在肿瘤中的保留和细胞摄取。
ACS Nano. 2013 Jul 23;7(7):6244-57. doi: 10.1021/nn402201w. Epub 2013 Jun 27.
10
Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles.1.9nm 金纳米颗粒的细胞类型依赖性摄取、定位和细胞毒性。
Int J Nanomedicine. 2012;7:2673-85. doi: 10.2147/IJN.S31751. Epub 2012 Jun 1.
引用本文的文献
1
Stealth and Biocompatible Gold Nanoparticles through Surface Coating with a Zwitterionic Derivative of Glutathione.通过用谷胱甘肽的两性离子衍生物进行表面涂层来实现隐形和生物相容的金纳米粒子。
Langmuir. 2024 Jun 11;40(23):12167-12178. doi: 10.1021/acs.langmuir.4c01123. Epub 2024 May 29.
2
Gold Nanoparticle-based Biosensors for Point-of-Care Diagnostics: A Review of Sensing Nanoparticle Applications and Future Prospects.用于即时诊断的基于金纳米颗粒的生物传感器：传感纳米颗粒应用及未来前景综述
Comb Chem High Throughput Screen. 2025;28(3):417-434. doi: 10.2174/0113862073293557240320065128.
3
Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers.两性离子纳米级药物递送系统克服生物屏障的最新进展。
Asian J Pharm Sci. 2024 Feb;19(1):100883. doi: 10.1016/j.ajps.2023.100883. Epub 2023 Dec 29.
4
-Sulfonyl amidine polypeptides: new polymeric biomaterials with conformation transition responsive to tumor acidity.-磺酰脒多肽：具有响应肿瘤酸度构象转变的新型高分子生物材料。
Chem Sci. 2023 Dec 20;15(5):1769-1781. doi: 10.1039/d3sc05504c. eCollection 2024 Jan 31.
5
Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery.将智能纳米系统与临床相关模型和先进成像技术相结合，实现精准药物输送。
Adv Sci (Weinh). 2024 Apr;11(14):e2308659. doi: 10.1002/advs.202308659. Epub 2024 Jan 28.
6
Biological Interaction and Imaging of Ultrasmall Gold Nanoparticles.超小金纳米颗粒的生物相互作用与成像
Nanomicro Lett. 2023 Dec 4;16(1):44. doi: 10.1007/s40820-023-01266-4.
7
A comprehensive approach to developing a multi-epitope vaccine against : from design to immunization evaluation.一种针对 的多表位疫苗的综合开发方法：从设计到免疫评估。
Front Immunol. 2023 Nov 2;14:1280299. doi: 10.3389/fimmu.2023.1280299. eCollection 2023.
8
Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.用于生物医学应用的生物正交纳米酶的模块化构建
Adv Mater. 2024 Mar;36(10):e2300943. doi: 10.1002/adma.202300943. Epub 2023 Oct 18.
9
Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars.理化性质和全身给药途径控制放射性标记金纳米星的体内动力学和降解。
Small. 2023 Jul;19(29):e2204293. doi: 10.1002/smll.202204293. Epub 2023 Mar 25.
10
Self-Therapeutic Nanomaterials: Applications in Biology and Medicine.自我治疗性纳米材料：在生物学和医学中的应用
Mater Today (Kidlington). 2023 Jan-Feb;62:190-224. doi: 10.1016/j.mattod.2022.11.007. Epub 2022 Nov 29.
本文引用的文献
1
Zwitterionic SAMs that Resist Nonspecific Adsorption of Protein from Aqueous Buffer.抵抗来自水性缓冲液中蛋白质非特异性吸附的两性离子自组装单分子膜。
Langmuir. 2001 May 1;17(9):2841-2850. doi: 10.1021/la0015258.
2
Fabrication of corona-free nanoparticles with tunable hydrophobicity.具有可调疏水性的无冠纳米颗粒的制备。
ACS Nano. 2014 Jul 22;8(7):6748-55. doi: 10.1021/nn5006478. Epub 2014 Jul 11.
3
Nanoparticles for imaging, sensing, and therapeutic intervention.用于成像、传感和治疗干预的纳米颗粒。
ACS Nano. 2014 Apr 22;8(4):3107-22. doi: 10.1021/nn500962q. Epub 2014 Mar 18.
4
Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles.蛋白质冠层可抑制亲水性和疏水性纳米颗粒的溶血活性。
Mater Horiz. 2014 Jan 1;1(1):102-105. doi: 10.1039/C3MH00075C.
5
Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles.生物刺激与生物分子在纳米级聚合物颗粒的组装与操控中的作用
Chem Sci. 2012 May 1;3(5). doi: 10.1039/C2SC00857B.
6
A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals.一种基于纳米颗粒的策略，通过非线性放大微环境信号来对广泛的肿瘤进行成像。
Nat Mater. 2014 Feb;13(2):204-12. doi: 10.1038/nmat3819. Epub 2013 Dec 8.
7
Stimuli-responsive nanocarriers for drug delivery.刺激响应型纳米载体用于药物递送。
Nat Mater. 2013 Nov;12(11):991-1003. doi: 10.1038/nmat3776.
8
Enhanced retention and cellular uptake of nanoparticles in tumors by controlling their aggregation behavior.通过控制纳米粒子的聚集行为来增强其在肿瘤中的保留和细胞摄取。
ACS Nano. 2013 Jul 23;7(7):6244-57. doi: 10.1021/nn402201w. Epub 2013 Jun 27.
9
Controlled pH stability and adjustable cellular uptake of mixed-charge nanoparticles.混合电荷纳米颗粒的可控 pH 稳定性和可调节细胞摄取。
J Am Chem Soc. 2013 May 1;135(17):6392-5. doi: 10.1021/ja4001272. Epub 2013 Apr 19.
10
Growth of highly fluorescent polyethylene glycol- and zwitterion-functionalized gold nanoclusters.高度荧光的聚乙二醇和两性离子功能化的金纳米簇的生长。
ACS Nano. 2013 Mar 26;7(3):2509-21. doi: 10.1021/nn305856t. Epub 2013 Feb 22.
Zotero 插件