蛋白质冠层可抑制亲水性和疏水性纳米颗粒的溶血活性。
Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles.
作者信息
Saha Krishnendu, Moyano Daniel F, Rotello Vincent M
机构信息
Department of Chemistry, 710 North Pleasant St, University of Massachusetts Amherst, Amherst, Massachusetts, USA 01003. ; Tel: 413-545-2058.
出版信息
Mater Horiz. 2014 Jan 1;1(1):102-105. doi: 10.1039/C3MH00075C.
Abstract
The role of nanoparticle surface hydrophobicity on its hemolytic property is established in the absence and the presence of plasma proteins. Significantly, the formation of plasma protein corona on NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis.
摘要
在有无血浆蛋白存在的情况下，均确定了纳米颗粒表面疏水性对其溶血特性的作用。值得注意的是，纳米颗粒表面血浆蛋白冠的形成可保护红细胞免受亲水性和疏水性纳米颗粒介导的溶血作用。
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2
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Nat Nanotechnol. 2012 Dec;7(12):779-86. doi: 10.1038/nnano.2012.207.
3
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J Nanosci Nanotechnol. 2012 Aug;12(8):6168-75. doi: 10.1166/jnn.2012.6433.
4
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10
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