Sahraian Ali, Ghanizadeh Ahmad, Kazemeini Fereshteh
Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran.
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Trials. 2015 Mar 14;16:94. doi: 10.1186/s13063-015-0609-1.
There are some animal studies suggesting the possible role of vitamin C for treating depression. However, the efficacy of vitamin C for treating adult patients with major depressive disorder (MDD) has never been examined.
This 8-week randomized double-blind placebo-controlled clinical trial included adult patients with major depressive disorder according to DSM-IV diagnostic criteria. Twenty-one patients in the treatment group received citalopram plus vitamin C and the 22 patients in the control group received citalopram plus placebo. The Hamilton Depression Rating Scale was used to measure depressive symptoms at baseline, week 2, week 4, and week 8. We also checked for the presence of adverse effects.
While depression symptoms decreased in both groups during this trial, there was no statistically significant difference between the 2 groups (P = .5). The rate of remission, partial response, and complete response was not different between the two groups. The rate of adverse effects were not different between the two groups.
Adding vitamin C to citalopram did not increase the efficacy of citalopram in MDD patients. Vitamin C plus citalopram is as effective as placebo plus citalopram for treating adult patients with suicidal behavior. No serious adverse effect for this combination was identified during this trial.
This trial was registered at http://www.irct.ir . The registration number of this trial was: IRCT201312263930N31 . Date registered: 5 July 2014.
有一些动物研究表明维生素C在治疗抑郁症方面可能发挥作用。然而，维生素C治疗成年重度抑郁症（MDD）患者的疗效从未得到检验。
这项为期8周的随机双盲安慰剂对照临床试验纳入了符合《精神疾病诊断与统计手册》第四版（DSM-IV）诊断标准的成年重度抑郁症患者。治疗组的21名患者接受西酞普兰加维生素C治疗，对照组的22名患者接受西酞普兰加安慰剂治疗。使用汉密尔顿抑郁量表在基线、第2周、第4周和第8周测量抑郁症状。我们还检查了不良反应的发生情况。
在该试验期间，两组的抑郁症状均有所减轻，但两组之间无统计学显著差异（P = 0.5）。两组的缓解率、部分缓解率和完全缓解率没有差异。两组的不良反应发生率没有差异。
在西酞普兰中添加维生素C并未提高其对MDD患者的疗效。维生素C加西酞普兰在治疗有自杀行为的成年患者方面与安慰剂加西酞普兰一样有效。在该试验期间未发现这种联合用药有严重不良反应。
该试验在http://www.irct.ir上注册。该试验的注册号为：IRCT201312263930N31。注册日期：2014年7月5日。
