美国人群中复合膳食抗氧化指数与自杀意念发生率及死亡率的关联。

Associations of composite dietary antioxidant index with suicidal ideation incidence and mortality among the U.S. population.

作者信息

Huang Shaoqun, Zhao Weimin, Choi Seok, Gong Hongyang

机构信息

Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

Department of Clinical Medicine, School of Medicine, Shihezi University, Shihezi, China.

出版信息

Front Nutr. 2024 Oct 7;11:1457244. doi: 10.3389/fnut.2024.1457244. eCollection 2024.

DOI:10.3389/fnut.2024.1457244

PMID:39434895

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11492068/

Abstract

BACKGROUND

The relationship between CDAI and suicidal ideation is unclear. This study investigates the relationship between CDAI and suicidal ideation and examines the association between CDAI and all-cause mortality (ACM) or cardiovascular disease mortality (CVM) among participants with and without suicidal ideation.

METHODS

Data from seven NHANES cycles (2005-2018) were analyzed using cross-sectional and prospective cohort studies. Weighted multivariable logistic regression models, restricted cubic spline (RCS) plots, and subgroup analyses explored the association between CDAI and suicidal ideation. Kaplan-Meier (KM) curves, weighted multivariable Cox proportional hazards models, and RCS assessed the relationship between CDAI and CVM or ACM.

RESULTS

Among 30,976 participants aged over 20, 1,154 (3.72%) had suicidal ideation. Higher CDAI levels (Quartile 4) were associated with a 28% reduction in suicidal ideation compared to lower levels (Quartile 1). Over an average follow-up of 89 months, 3,267 participants (7.6%) died, including 808 (1.8%) from cardiovascular causes. Higher CDAI levels were linked to a 30, 68, and 28% reduction in ACM in the total population, those with suicidal ideation, and those without, respectively. CVM was reduced by 40% in the total population and by 41% in those without suicidal ideation.

CONCLUSION

CDAI is negatively associated with suicidal ideation and correlated with reduced ACM and CVM among participants with and without suicidal ideation.

摘要

背景

临床抑郁自评量表（CDAI）与自杀意念之间的关系尚不清楚。本研究调查了CDAI与自杀意念之间的关系，并检验了有自杀意念和无自杀意念参与者中CDAI与全因死亡率（ACM）或心血管疾病死亡率（CVM）之间的关联。

方法

使用横断面研究和前瞻性队列研究分析了来自七个国家健康与营养检查调查（NHANES）周期（2005 - 2018年）的数据。加权多变量逻辑回归模型、受限立方样条（RCS）图和亚组分析探讨了CDAI与自杀意念之间的关联。Kaplan - Meier（KM）曲线、加权多变量Cox比例风险模型和RCS评估了CDAI与CVM或ACM之间的关系。

结果

在30976名20岁以上的参与者中，1154人（3.72%）有自杀意念。与较低水平（四分位数1）相比，较高的CDAI水平（四分位数4）与自杀意念降低28%相关。在平均89个月的随访中，3267名参与者（7.6%）死亡，其中808人（1.8%）死于心血管疾病。较高的CDAI水平分别与总体人群、有自杀意念者和无自杀意念者的ACM降低30%、68%和28%相关。总体人群中CVM降低了40%，无自杀意念者中降低了41%。