Yuan Xianli, Peng Xiao, Li Yan, Li Mingcai
Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.
Mediators Inflamm. 2015;2015:807976. doi: 10.1155/2015/807976. Epub 2015 Mar 19.
Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.
白细胞介素-（IL-）38是最近发现的一种细胞因子，是IL-1细胞因子家族的第十个成员。IL-38与IL-1受体拮抗剂（IL-1Ra）和IL-36Ra具有结构特征。IL-36R是IL-38的特异性受体，是IL-36的部分受体拮抗剂。IL-38抑制T细胞细胞因子IL-17和IL-22的产生。IL-38还抑制IL-36γ诱导的IL-8的产生，从而抑制炎症反应。包括IL-1Ra和IL-36Ra在内的与IL-38相关的细胞因子参与炎症和免疫反应的调节。对IL-38和与IL-38相关的细胞因子的研究可能在不久的将来为开发抗炎治疗提供新的见解。
