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镧、便秘、令人困惑的X光检查与结肠憩室穿孔

Lanthanum, constipation, bafflying X-rays and a perforated colonic diverticulum.

作者信息

Korzets Asher, Tsitman Inna, Lev Netta, Zingerman Boris, Herman Michal, Ben Dor Naomi, Gafter Uzi, Ori Yaacov

机构信息

Department of Nephrology and Hypertension , Hasharon Hospital, Rabin Medical Center, Sackler School of Medicine , Tel Aviv University , Israel.

Department of Radiology , Hasharon Hospital, Rabin Medical Center, Sackler School of Medicine , Tel Aviv University , Israel.

出版信息

Clin Kidney J. 2012 Aug;5(4):331-3. doi: 10.1093/ckj/sfs073. Epub 2012 Jul 6.

DOI:10.1093/ckj/sfs073
PMID:25874091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4393478/
Abstract

Lanthanum carbonate (LC) is used as a phosphate binder in dialysed patients. Abdominal pain and constipation are known side effects of its use. Furthermore, in radiological studies, LC tablets are seen as intense radio-opaque deposits within the entire gastrointestinal tract-findings which can lead to diagnostic misinterpretations. An elderly patient on peritoneal dialysis and taking LC presented with peritonitis, secondary to a perforated colonic diverticulum. The possible association between the use of LC, worsening constipation and complications arising from colonic diverticular disease, are discussed.

摘要

碳酸镧（LC）被用作透析患者的磷结合剂。腹痛和便秘是其已知的副作用。此外，在放射学研究中，LC片剂在整个胃肠道内表现为强烈的不透射线沉积物，这些发现可能导致诊断错误。一名接受腹膜透析并服用LC的老年患者出现了因结肠憩室穿孔继发的腹膜炎。本文讨论了使用LC、便秘加重与结肠憩室病引起的并发症之间可能存在的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abb/4393478/3a88175bdbb1/sfs07302.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abb/4393478/a80e1ef76305/sfs07301.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abb/4393478/3a88175bdbb1/sfs07302.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abb/4393478/a80e1ef76305/sfs07301.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abb/4393478/3a88175bdbb1/sfs07302.jpg

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本文引用的文献

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Intestinal pseudo-obstruction secondary to persistent constipation due to lanthanum carbonate.
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2
Pharmacology of the phosphate binder, lanthanum carbonate.磷酸盐结合剂碳酸镧的药理学。
Ren Fail. 2011;33(2):217-24. doi: 10.3109/0886022X.2011.552821.
3
Colonic opacification in a patient with end-stage kidney disease.
Gastroenterology. 2010 Sep;139(3):e8-9. doi: 10.1053/j.gastro.2009.10.066. Epub 2010 Jul 30.
4
Beam-hardening artifacts on computed tomography images caused by lanthanum carbonate hydrate in a patient on dialysis.透析患者体内碳酸镧水合物导致 CT 图像出现束硬化伪影。
Jpn J Radiol. 2010 May;28(4):322-4. doi: 10.1007/s11604-010-0426-0. Epub 2010 May 29.
5
Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure.慢性肾衰竭大鼠组织中镧与铝的蓄积——长期暴露后可能产生的有害影响。
Nephron Exp Nephrol. 2010;115(4):e112-21. doi: 10.1159/000313492. Epub 2010 Apr 28.
6
Accumulation of lanthanum carbonate in the digestive tracts.
Clin Exp Nephrol. 2010 Feb;14(1):100-1. doi: 10.1007/s10157-009-0240-0. Epub 2009 Nov 6.
7
A confusional state associated with use of lanthanum carbonate in a dialysis patient: a case report.
Nephrol Dial Transplant. 2009 Oct;24(10):3245-7. doi: 10.1093/ndt/gfp340. Epub 2009 Jul 13.
8
Lanthanum and phosphate: science, policy, and survival.
Kidney Int. 2009 Feb;75(4):355-7. doi: 10.1038/ki.2008.627.
9
Long-term efficacy and safety profile of lanthanum carbonate: results for up to 6 years of treatment.碳酸镧的长期疗效和安全性概况：长达6年的治疗结果
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