Department of Gastroenterology, Japan Community Health Care Organization Sendai Hospital, Japan.
Department of Hospital Medicine, Japan Community Health Care Organization Sendai Hospital, Japan.
Intern Med. 2021 Feb 1;60(3):379-384. doi: 10.2169/internalmedicine.5231-20. Epub 2020 Aug 29.
Appropriate management of constipation in hemodialysis patients has not been established, although constipation is the most frequent gastrointestinal complication in dialysis patients. We herein report the efficacy and safety of polyethylene glycol in constipated hemodialysis patients assessed prospectively. Seven patients using stimulant laxatives participated in this study. Polyethylene glycol was administered to reduce stimulant laxatives during the six-week intervention period. The amount of stimulant laxatives decreased and spontaneous bowel movements with ideal stool consistency increased significantly after the intervention. No serious adverse effects were observed throughout this study. In conclusion, polyethylene glycol can be a useful tool for managing constipated hemodialysis patients.
尽管便秘是透析患者最常见的胃肠道并发症，但对于透析患者便秘的恰当处理方法尚未明确。我们在此前瞻性报告了聚乙二醇治疗便秘型透析患者的疗效和安全性。本研究纳入了 7 名使用刺激性泻药的患者。在 6 周的干预期间，给予聚乙二醇以减少刺激性泻药的使用。干预后，刺激性泻药的用量减少，且理想便质的自发排便次数显著增加。整个研究过程中未观察到严重不良反应。综上，聚乙二醇可能是治疗便秘型透析患者的一种有效工具。
