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与帕金森病相比，多系统萎缩和进行性核上性麻痹中的疼痛。

Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease.

作者信息

Kass-Iliyya Lewis, Kobylecki Christopher, McDonald Kathryn R, Gerhard Alexander, Silverdale Monty A

机构信息

Department of Neurology, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust Stott Lane, M6 8HD, Salford, U.K ; Centre for Clinical and Cognitive Neurosciences, Institute of Brain Behaviour and Mental Health, University of Manchester Manchester, U.K.

Centre for Clinical and Cognitive Neurosciences, Institute of Brain Behaviour and Mental Health, University of Manchester Manchester, U.K.

出版信息

Brain Behav. 2015 May;5(5):e00320. doi: 10.1002/brb3.320. Epub 2015 Mar 25.

DOI:10.1002/brb3.320
PMID:25874161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4389053/
Abstract

BACKGROUND

Pain is a common nonmotor symptom in Parkinson's disease (PD). The pathophysiology of pain in PD is not well understood. Pain characteristics have rarely been studied in atypical parkinsonian disorders such as Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP).

AIM OF THE STUDY

We aimed to evaluate pain intensity, location, and associated symptoms in atypical parkinsonian disorders compared to PD.

METHODS

Twenty-one patients with MSA, 16 patients with PSP, and 65 patients with PD were screened for pain using question 1.9 of the MDS-UPDRS. Pain intensity was quantified using the short form McGill Pain Questionnaire (SFMPQ). Pain locations were documented. Motor disability was measured using UPDRS-III. Affective symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS).

RESULTS

Pain was significantly more common and more severe in PD and MSA compared to PSP (P < 0.01). Pain locations were similar with limb pain being the most common followed by neck and back pain. Pain intensity correlated with HADS scores but not motor severity.

CONCLUSIONS

Pain is more common and more intense in PD and MSA than PSP. Differences in distribution of neurodegenerative pathologies may underlie these differential pain profiles.

摘要

背景

疼痛是帕金森病（PD）常见的非运动症状。PD疼痛的病理生理学尚未完全明确。在多系统萎缩（MSA）和进行性核上性麻痹（PSP）等非典型帕金森病中，疼痛特征鲜有研究。

研究目的

我们旨在评估非典型帕金森病与PD相比的疼痛强度、部位及相关症状。

方法

使用MDS-UPDRS的问题1.9对21例MSA患者、16例PSP患者和65例PD患者进行疼痛筛查。使用简式麦吉尔疼痛问卷（SFMPQ）对疼痛强度进行量化。记录疼痛部位。使用UPDRS-III评估运动功能障碍。使用医院焦虑抑郁量表（HADS）评估情感症状。

结果

与PSP相比，PD和MSA中的疼痛明显更常见且更严重（P < 0.01）。疼痛部位相似，肢体疼痛最为常见，其次是颈部和背部疼痛。疼痛强度与HADS评分相关，但与运动严重程度无关。

结论

PD和MSA中的疼痛比PSP更常见且更严重。神经退行性病变分布的差异可能是这些不同疼痛特征的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c6/4430244/320eefb48b50/brb30005-e00320-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c6/4430244/26a3141d68ec/brb30005-e00320-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c6/4430244/320eefb48b50/brb30005-e00320-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c6/4430244/26a3141d68ec/brb30005-e00320-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c6/4430244/320eefb48b50/brb30005-e00320-f2.jpg

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