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新型肽树枝状大分子PDL-GB2和PDL-G2的合成

Synthesis of novel peptide dendrimers PDL-GB2 and PDL-G2.

作者信息

Yunzhu Lin, Lingling Weng, Qingrong Qi

机构信息

Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, China ; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China.

Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.

出版信息

ScientificWorldJournal. 2015;2015:907859. doi: 10.1155/2015/907859. Epub 2015 Mar 22.

DOI:10.1155/2015/907859
PMID:25874261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4385662/
Abstract

Peptide dendrimers are a novel type of macromolecules with precise structure, which can be used as drug target vector and controlled-release carrier. So it is valuable to study. In this paper, novel peptide dendrimers PDL-GB2 and PDL-G2 were prepared according to divergent procedure with four-orientation molecule as the core and L-lysine as the branch unit. And the structures were identified by 1HNMR, 13CNMR, MS, and elemental analysis.

摘要

肽树枝状大分子是一类结构精确的新型大分子，可作为药物靶向载体和控释载体。因此，对其进行研究具有重要价值。本文以四向性分子为核心、L-赖氨酸为支化单元，采用发散法制备了新型肽树枝状大分子PDL-GB2和PDL-G2。并通过1HNMR、13CNMR、MS和元素分析对其结构进行了鉴定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/9dad57a32e9c/TSWJ2015-907859.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/80ee8b863547/TSWJ2015-907859.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/455274fbcc86/TSWJ2015-907859.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/20c344152b2d/TSWJ2015-907859.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/bc0bb0111ddc/TSWJ2015-907859.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/9dad57a32e9c/TSWJ2015-907859.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/80ee8b863547/TSWJ2015-907859.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/455274fbcc86/TSWJ2015-907859.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/20c344152b2d/TSWJ2015-907859.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/bc0bb0111ddc/TSWJ2015-907859.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68a3/4385662/9dad57a32e9c/TSWJ2015-907859.003.jpg

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本文引用的文献

1
Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells.设计的细胞穿透肽树枝状大分子能有效地将货物内化到细胞中。
Chem Commun (Camb). 2014 Jul 14;50(55):7254-7. doi: 10.1039/c4cc02780a.
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Asymmetric peptide dendrimers are effective linkers for antibody-mediated delivery of diverse payloads to b cells in vitro and in vivo.不对称肽树枝状大分子是在体外和体内将多种有效载荷通过抗体介导递送至B细胞的有效连接物。
Pharm Res. 2014 Nov;31(11):3150-60. doi: 10.1007/s11095-014-1408-1. Epub 2014 May 22.
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Interplay of stimuli-responsiveness, drug loading and release for a surface-engineered dendrimer delivery system.
用于表面工程树枝状大分子递送系统的刺激响应性、药物负载与释放的相互作用
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Computationally efficient methodology for atomic-level characterization of dendrimer-drug complexes: a comparison of amine- and acetyl-terminated PAMAM.用于树枝状聚合物-药物复合物原子水平表征的计算高效方法：胺基和乙酰基封端的 PAMAM 的比较。
J Phys Chem B. 2013 Jun 6;117(22):6801-13. doi: 10.1021/jp4000363. Epub 2013 May 22.
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The anti-tumor efficiency of poly(L-glutamic acid) dendrimers with polyhedral oligomeric silsesquioxane cores.具有多面体低聚倍半硅氧烷核的聚（L-谷氨酸）树枝状聚合物的抗肿瘤效率。
Biomaterials. 2013 May;34(14):3658-66. doi: 10.1016/j.biomaterials.2013.01.082. Epub 2013 Feb 20.
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Development and optimization of thiolated dendrimer as a viable mucoadhesive excipient for the controlled drug delivery: an acyclovir model formulation.作为一种可行的黏膜黏附赋形剂，用于控制药物传递：阿昔洛韦模型制剂的硫醇化树枝状大分子的开发和优化。
Nanomedicine. 2013 May;9(4):514-22. doi: 10.1016/j.nano.2012.10.005. Epub 2012 Oct 29.
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Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization.肽树状聚合物作为高效、生物相容的基因传递载体：合成与体外特性分析。
J Control Release. 2011 Oct 10;155(1):77-87. doi: 10.1016/j.jconrel.2010.10.006. Epub 2010 Oct 12.
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Penicillin V-conjugated PEG-PAMAM star polymers.青霉素V共轭聚乙二醇-聚酰胺-胺型星状聚合物
J Biomater Sci Polym Ed. 2003;14(10):1043-56. doi: 10.1163/156856203769231556.
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A PEGylated dendritic nanoparticulate carrier of fluorouracil.一种氟尿嘧啶的聚乙二醇化树枝状纳米颗粒载体。
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