Os'minkin D
Bjuro sudebno-meditsinskoj ekspertizy Minzdrava Udmurtskoj Respubliki, Izhevsk, Rossija, 426009.
Sud Med Ekspert. 2015 Jan-Feb;58(1):18-21. doi: 10.17116/sudmed201558118-21.
The objective of the present study was to evaluate the results of the microscopic studies of acute intoxication with ethyl alcohol at the territory of the Udmurtian Republic during the period from 2003 till 2013. A total of 5941 cases of death caused by acute intoxication with ethyl alcohol were documented among both men and women, largely able-bodied ones. Concentration of ethyl alcohol in their blood corresponded to the one known to result in severe or lethal intoxication, The forensic histological study of the available tissue samples gave evidence of vascular disturbances, enhanced permeability of the vascular walls, dystrophic changes in the internal organs, the signs of necronephrosis, and concomitant disorders. Epithelium of renal tubules obtained from 0.4% of the corpses contained the pigment particles of different structure and colour; other pathological changes included cholestasis, necrosis of hepatocytes, various lesions and injuries. Similar alterations were identified in the detoxificating organs of the subjects who had died from causes other than acute intoxication with ethyl alcohol. These findings suggest disturbances of pigment metabolism and make it possible to elucidate the peculiar features of patho- and tanatogenesis.
本研究的目的是评估2003年至2013年期间在乌德穆尔特共和国境内对急性乙醇中毒进行微观研究的结果。在男性和女性中，共记录了5941例由急性乙醇中毒导致的死亡病例，其中大部分为身体健全者。他们血液中的乙醇浓度与已知会导致严重或致命中毒的浓度相符。对现有组织样本进行的法医组织学研究表明存在血管紊乱、血管壁通透性增强、内脏营养不良性变化、肾坏死迹象以及伴随的病症。从0.4%的尸体中获取的肾小管上皮含有不同结构和颜色的色素颗粒；其他病理变化包括胆汁淤积、肝细胞坏死、各种病变和损伤。在死于急性乙醇中毒以外原因的受试者的解毒器官中也发现了类似的改变。这些发现提示色素代谢紊乱，并有助于阐明病理发生和死亡发生的特殊特征。
