Shu Jian-Jun, Wang Qi-Wen, Yong Kian-Yan, Shao Fangwei, Lee Kee Jin
J Phys Chem B. 2015 Apr 30;119(17):5639-44. doi: 10.1021/acs.jpcb.5b02165. Epub 2015 Apr 21.
Because of DNA appealing features as perfect material, including minuscule size, defined structural repeat and rigidity, programmable DNA-mediated processing is a promising computing paradigm, which employs DNAs as information storing and processing substrates to tackle the computational problems. The massive parallelism of DNA hybridization exhibits transcendent potential to improve multitasking capabilities and yield a tremendous speed-up over the conventional electronic processors with stepwise signal cascade. As an example of multitasking capability, we present an in vitro programmable DNA-mediated optimal route planning processor as a functional unit embedded in contemporary navigation systems. The novel programmable DNA-mediated processor has several advantages over the existing silicon-mediated methods, such as conducting massive data storage and simultaneous processing via much fewer materials than conventional silicon devices.
由于DNA具有作为完美材料的吸引人的特性，包括极小的尺寸、明确的结构重复和刚性，可编程DNA介导的处理是一种很有前途的计算范式，它将DNA用作信息存储和处理的底物来解决计算问题。DNA杂交的大规模并行性在提高多任务处理能力方面具有卓越的潜力，并且与具有逐步信号级联的传统电子处理器相比，能实现巨大的加速。作为多任务处理能力的一个例子，我们展示了一种体外可编程DNA介导的最优路径规划处理器，作为嵌入当代导航系统的功能单元。这种新型可编程DNA介导的处理器相对于现有的硅介导方法具有几个优点，例如通过比传统硅器件少得多的材料进行海量数据存储和同时处理。
