van Drielen Kelly, Gunn David A, Noordam Raymond, Griffiths Christopher E M, Westendorp Rudi G J, de Craen Anton J M, van Heemst Diana
Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.
Age (Dordr). 2015 Jun;37(3):9771. doi: 10.1007/s11357-015-9771-3. Epub 2015 Apr 16.
Circulatory levels of insulin-like growth factor (IGF-1), glucose, and cortisol have been previously associated with facial aging. However, as these serum measures are related, it is unclear whether their associations with skin aging occur independently from each other. We aimed to investigate whether the associations between serum IGF-1, glucose, and cortisol levels and perceived age/wrinkle grade occur independently of each other and whether these are mediated via skin wrinkling or via other skin aging features. Perceived age and skin wrinkling grade were assessed in a random sample from the Leiden Longevity Study with non-fasted (N = 579) and fasted blood sampling (N = 219). In our study population, a higher non-fasted IGF-1 level was associated with a lower skin wrinkling grade (p value = 0.014) and tended to associate with a lower perceived age (p value = 0.067), which was mediated for approximately 100 % by skin wrinkling. A higher non-fasted glucose level was associated with a higher perceived age (p value = 0.017), which was mediated for 51 % by skin wrinkling grade (p value = 0.112). A higher fasted cortisol level tended to associate with a higher perceived age (p value = 0.116), which was mediated for 29 % by skin wrinkling. Results remained similar when the serum measures were statistically adjusted for each other. Thus, the previously reported serum measures associate independently from each other with skin aging. IGF-1 is predominantly associated with perceived age by skin wrinkling, whereas cortisol and glucose also by other skin aging features.
胰岛素样生长因子（IGF-1）、葡萄糖和皮质醇的循环水平此前已被证实与面部衰老有关。然而，由于这些血清指标之间存在关联，目前尚不清楚它们与皮肤衰老之间的关联是否相互独立。我们旨在研究血清IGF-1、葡萄糖和皮质醇水平与感知年龄/皱纹等级之间的关联是否相互独立，以及这些关联是通过皮肤皱纹还是其他皮肤衰老特征介导的。我们从莱顿长寿研究中随机抽取样本，分别进行非空腹（N = 579）和空腹血液采样（N = 219），评估感知年龄和皮肤皱纹等级。在我们的研究人群中，较高的非空腹IGF-1水平与较低的皮肤皱纹等级相关（p值 = 0.014），并且倾向于与较低的感知年龄相关（p值 = 0.067），其中约100%是由皮肤皱纹介导的。较高的非空腹血糖水平与较高的感知年龄相关（p值 = 0.017），其中51%是由皮肤皱纹等级介导的（p值 = 0.112）。较高的空腹皮质醇水平倾向于与较高的感知年龄相关（p值 = 0.116），其中29%是由皮肤皱纹介导的。当对血清指标进行相互统计调整时，结果仍然相似。因此，先前报道的血清指标与皮肤衰老之间相互独立相关。IGF-1主要通过皮肤皱纹与感知年龄相关，而皮质醇和葡萄糖还通过其他皮肤衰老特征与之相关。
