Kaur Jasdeep, Jacobs Reinhilde
OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Leuven, Belgium.
Oral and Maxillo-facial Surgery, University Hospitals Leuven, Leuven, Belgium.
Clin Oral Investig. 2016 Jan;20(1):39-42. doi: 10.1007/s00784-015-1472-x. Epub 2015 Apr 16.
Leptin levels are associated with appetite and energy expenditure in healthy individuals. The present study aims to evaluate serum and salivary leptin concentrations in patients with squamous cell carcinoma of the buccal mucosa.
Enrolled participants in this study included 41 patients with squamous cell carcinoma of the buccal mucosa and 40 healthy control patients. Serum leptin levels were measured via enzyme-linked immunosorbent assay (ELISA) method in all subjects and reported in units of nanograms per millilitre. Salivary leptin levels were measured by a highly sensitive and specific non-equilibrium version of a dedicated custom radioimmunoassay.
A significant reduction in salivary and serum leptin levels in patients with squamous cell carcinoma of the buccal mucosa was observed in comparison to control subjects. In addition, a significant correlation was shown between serum and salivary leptin levels on one hand and body mass index, with various histopathological and TNM (tumour nodes metastasis) staging variants of squamous cell carcinoma of the buccal mucosa on another. A highly significant correlation was shown between salivary and serum leptin levels in both groups.
The results of this study demonstrate a possible mechanism of salivary and serum leptin levels in squamous cell carcinoma of the buccal mucosa.
Salivary leptin might play a role in squamous cell carcinoma of the buccal mucosa.
在健康个体中，瘦素水平与食欲和能量消耗相关。本研究旨在评估颊黏膜鳞状细胞癌患者的血清和唾液瘦素浓度。
本研究纳入的参与者包括41例颊黏膜鳞状细胞癌患者和40例健康对照者。采用酶联免疫吸附测定（ELISA）法测量所有受试者的血清瘦素水平，并以每毫升纳克为单位报告。唾液瘦素水平通过一种高度敏感且特异的专用定制放射免疫测定的非平衡版本进行测量。
与对照受试者相比，观察到颊黏膜鳞状细胞癌患者的唾液和血清瘦素水平显著降低。此外，一方面血清和唾液瘦素水平与体重指数之间，另一方面与颊黏膜鳞状细胞癌的各种组织病理学和TNM（肿瘤淋巴结转移）分期变体之间均显示出显著相关性。两组的唾液和血清瘦素水平之间均显示出高度显著的相关性。
本研究结果揭示了颊黏膜鳞状细胞癌中唾液和血清瘦素水平的一种可能机制。
唾液瘦素可能在颊黏膜鳞状细胞癌中发挥作用。
