Bolukbas F Fusun, Kilic Hasan, Bolukbas Cengiz, Gumus Mahmut, Horoz Mehmet, Turhal Nazim S, Kavakli Birsel
Harran University Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Sanliurfa, Turkey.
BMC Cancer. 2004 Jun 24;4:29. doi: 10.1186/1471-2407-4-29.
Serum leptin level is associated with appetite and energy expenditure in healthy individuals. We aimed to evaluate the serum leptin concentration and the other factors which may be associated with weight loss in patients with advanced gastrointestinal cancer.
Forty-four patients with advanced gastrointestinal cancer (25 gastric and 19 colorectal cancer) and 25 healthy controls were enrolled. Serum leptin levels were measured as ng/ml via enzyme linked immuno-sorbent assay (ELISA) method in all subjects. The difference in serum leptin concentration between cancer and control group, the factor associated with its serum level and the relationship between serum leptin concentration and weight loss was evaluated.
Serum leptin concentration of cancer group was significantly lower than controls (p = 0.002). Female subjects had significantly higher serum leptin concentration than male subjects in control group (p = 0.01), while not in cancer group (p > 0.05). Serum leptin concentration was significantly related with gender in controls (p = 0.023, beta = 0.479), while no gender difference was observed in cancer group (p > 0.05). No relationship was found between serum leptin concentration and weight loss percentage in cancer group in linear regression analysis (p > 0.05). No significant difference was observed in serum leptin concentrations between colon and gastric cancer sub-groups (p > 0.05).
Independently from the site of gastrointestinal tract, serum leptin concentration in advanced gastrointestinal cancer is lower than controls and it is not a determinant factor in weight loss. In contrast to healthy subjects, gender does not effect the serum leptin concentration in patients with advanced gastrointestinal cancer.
血清瘦素水平与健康个体的食欲和能量消耗相关。我们旨在评估晚期胃肠道癌患者的血清瘦素浓度以及其他可能与体重减轻相关的因素。
纳入44例晚期胃肠道癌患者（25例胃癌和19例结直肠癌）和25例健康对照者。采用酶联免疫吸附测定（ELISA）法测定所有受试者血清瘦素水平，单位为ng/ml。评估癌症组与对照组血清瘦素浓度的差异、与其血清水平相关的因素以及血清瘦素浓度与体重减轻之间的关系。
癌症组血清瘦素浓度显著低于对照组（p = 0.002）。对照组中女性受试者血清瘦素浓度显著高于男性受试者（p = 0.01），而癌症组中无此差异（p > 0.05）。对照组中血清瘦素浓度与性别显著相关（p = 0.023，β = 0.479），而癌症组中未观察到性别差异（p > 0.05）。线性回归分析显示癌症组血清瘦素浓度与体重减轻百分比之间无相关性（p > 0.05）。结肠癌和胃癌亚组之间血清瘦素浓度无显著差异（p > 0.05）。
晚期胃肠道癌患者血清瘦素浓度低于对照组，且与胃肠道部位无关，它不是体重减轻的决定因素。与健康受试者不同，性别对晚期胃肠道癌患者血清瘦素浓度无影响。
