硫酸孕烯醇酮可拮抗巴比妥酸盐诱导的催眠作用。
Pregnenolone sulfate antagonizes barbiturate-induced hypnosis.
作者信息
Majewska M D, Bluet-Pajot M T, Robel P, Baulieu E E
机构信息
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
出版信息
Pharmacol Biochem Behav. 1989 Jul;33(3):701-3. doi: 10.1016/0091-3057(89)90410-3.
PMID:2587612
Abstract
The potential influence of the neurosteroid pregnenolone sulfate (PrS) on barbiturate-induced hypnosis was tested in rats. PrS, when injected intracerebroventricularly or intraperitoneally, significantly shortened the sleep-time produced by pentobarbital. The results suggest an important physiological and pharmacological role for PrS in the regulation of CNS excitability.
摘要
在大鼠中测试了神经甾体硫酸孕烯醇酮（PrS）对巴比妥类药物诱导催眠作用的潜在影响。当脑室内或腹腔内注射PrS时，显著缩短了戊巴比妥产生的睡眠时间。结果表明PrS在调节中枢神经系统兴奋性方面具有重要的生理和药理作用。
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