Pickworth M J, Dendy P P, Twentyman P R, Leighton T G
Department of Medical Physics, Addenbrooke's Hospital, Cambridge, UK.
Phys Med Biol. 1989 Nov;34(11):1553-60. doi: 10.1088/0031-9155/34/11/004.
In previous work the phenomenon of sonoluminescence (SL) has been used to find the conditions in which transient cavitation during exposure to ultrasound is likely to be maximum. This paper reports the effect of therapeutic ultrasound on growth of mouse tumour cells in monolayer culture when the cells are insonated either at a pressure antinode or at a pressure node in a standing wave ultrasound field that is known to produce strong bands of SL at the pressure antinodes. Reduced cell numbers 72 h after insonation were recorded when the cells were insonated at an antinode but not when they were at a node. The possibility that this effect might be an artefact of the experimental system, and further experiments that could elucidate the nature of the damage, are discussed.
在之前的工作中，声致发光（SL）现象已被用于寻找在超声暴露期间瞬态空化可能达到最大值的条件。本文报道了在已知在压力波腹处产生强烈声致发光带的驻波超声场中，当单层培养的小鼠肿瘤细胞在压力波腹或压力波节处被超声辐照时，治疗性超声对其生长的影响。当细胞在波腹处被辐照时，记录到辐照72小时后细胞数量减少，而在波节处辐照时则未出现这种情况。讨论了这种效应可能是实验系统假象的可能性，以及能够阐明损伤性质的进一步实验。
