Yang Jin-Liang, Zhang Rong, Du Lei, Yang Yun-Shuang, Liu Xiao-Chen
Zhongguo Zhen Jiu. 2014 Dec;34(12):1165-8.
To evaluate the effect mechanism of warm acupuncture combined with auricular point sticking therapy and its efficacy on insomnia by monitoring the level of brain neurotransmitters in the insomnia patients.
One hundred and thirty patients with insomnia were randomized into an observation group and a control group, 65 cases in each one. In the observation group, based on the treating principle of warming yang and benefiting qi, acupuncture was applied to Xinshu (BL 15), Pishu (BL 20), Shenshu (BL 23), Yaoyangguan (GV 3), Baihui (GV 20), Neiguan (PC 6) and Shenmen (HT 7). Warm acupuncture was supplemented at Xinshu (BL 15), Pishu (BL 20), Shenshu (BL 23) and Yaoyangguan (GV 3). The treatment was given once every day. In the control group, estazolam tablets, 0. 5 to 1 mg were prescribed for oral administration, 30 min before sleep at night. The treatment of 14 days was taken as one session and 2 sessions were required in the two groups. The encephal of luctuograph technology was used to observe the sleep quality and brain neurotransmitters before and after treatment in the two groups and the efficacy was compared between the two groups.
The total effective rate was 83.1% (54/65) in the observation group and 87.7% (57/65) in the control group. The efficacy was similar between the two groups (P > 0.05). In the observation group, after treatment, 5-HT and GABA/Glu were all increased compared with those before treatment (P < 0.05, P < 0.01) and norepinephrine (NE) was reduced compared with that before treatment (P < 0.05). The level of each index did not change significantly before and after treatment in the control group (all P > 0.05). The regulations of 5-HT, GABA/Glu in the observation group were superior to those in the control group (all P < 0.05).
The combined therapy of warm acupuncture and auricular point sticking method for warming yang and benefiting qi effectively improves brain neurotransmitters and essentially improves sleep quality of the patients with insomnia differentiated as yang deficiency pattern.
通过监测失眠患者脑内神经递质水平，探讨温针灸联合耳穴贴压疗法治疗失眠的作用机制及疗效。
将130例失眠患者随机分为观察组和对照组，每组65例。观察组采用温阳益气法，针刺心俞（BL 15）、脾俞（BL 20）、肾俞（BL 23）、腰阳关（GV 3）、百会（GV 20）、内关（PC 6）、神门（HT 7），并在心俞（BL 15）、脾俞（BL 20）、肾俞（BL 23）、腰阳关（GV 3）加用温针灸，每日1次。对照组于每晚睡前30 min口服艾司唑仑片0.5～1 mg。两组均以14天为1个疗程，共治疗2个疗程。采用脑电地形图技术观察两组治疗前后睡眠质量及脑内神经递质变化，并比较两组疗效。
观察组总有效率为83.1%（54/65），对照组为87.7%（57/65），两组疗效相当（P＞0.05）。观察组治疗后5-羟色胺（5-HT）、γ-氨基丁酸/谷氨酸（GABA/Glu）较治疗前升高（P＜0.05，P＜0.01），去甲肾上腺素（NE）较治疗前降低（P＜0.05）；对照组治疗前后各指标水平无明显变化（均P＞0.05）。观察组5-HT、GABA/Glu改善情况优于对照组（均P＜0.05）。
温针灸联合耳穴贴压温阳益气法能有效改善失眠患者的脑内神经递质，从根本上改善阳虚型失眠患者的睡眠质量。
