Department of Otolaryngology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Medicine (Baltimore). 2023 Sep 29;102(39):e35019. doi: 10.1097/MD.0000000000035019.
OBJECTIVE: To provide evidence for medical management of tinnitus based on an assessment of the evidence concerning the effectiveness of acupuncture as a treatment for tinnitus using network meta-analysis (NMA). METHODS: We conducted a systematic literature review by searching 8 national and international databases (inception to February 2023) for randomized controlled trials (RCTs) for tinnitus. Only RCTs that recruited participants aged over 18 and diagnosed with tinnitus, and that evaluated acupuncture or acupuncture in combination with conventional western medical therapy were included. We used response rate and tinnitus handicap inventory (THI) to examine efficacy. We conducted NMA with random effects, and the rate ratio or mean difference with its 95% credible interval was calculated. In addition, we ranked all treatments via their SUCRA and assessed the quality of evidence according to the GRADE criteria. RESULTS: A total of 2575 patients were included in the study. The main findings of the current NMA were that acupoint injection combined with warm acupuncture was the most effective for response rate, followed by warm acupuncture and acupoint injection combined with western medical treatment. Acupuncture combined with western medical treatment was the most effective for THI, followed by electroacupuncture combined with warm acupuncture and acupuncture combined with moxibustion. CONCLUSION: Acupuncture seems to be a better trend treatment for tinnitus. Further rigorous RCT studies that include direct comparisons for different acupuncture-related treatments are encouraged to provide the most promising evidence for patients with tinnitus. PROTOCOL REGISTRATION: CRD42023398745.
目的:通过评估针刺治疗耳鸣的有效性证据,为耳鸣的医学管理提供依据,采用网络荟萃分析(NMA)。
方法:我们系统地检索了 8 个国内外数据库(从创建到 2023 年 2 月),以查找耳鸣的随机对照试验(RCT),纳入了仅招募年龄超过 18 岁且被诊断为耳鸣的参与者,并评估了针刺或针刺联合常规西医治疗的 RCT。我们使用反应率和耳鸣残疾量表(THI)来评估疗效。我们采用随机效应进行 NMA,并计算了率比或均数差值及其 95%可信区间。此外,我们通过 SUCRA 对所有治疗方法进行了排名,并根据 GRADE 标准评估证据质量。
结果:共有 2575 名患者纳入研究。目前 NMA 的主要发现是,穴位注射联合温针灸对反应率最有效,其次是温针灸和穴位注射联合西医治疗。针刺联合西医治疗对 THI 最有效,其次是电针联合温针灸和针刺联合艾灸。
结论:针刺似乎是治疗耳鸣的一种更好的趋势治疗方法。鼓励进一步进行严格的 RCT 研究,包括对不同与针刺相关的治疗方法进行直接比较,为耳鸣患者提供最有希望的证据。
协议注册:CRD42023398745。
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