Vosoughi Reza, Marriott James J
Section of Neurology, University of Manitoba, Health Sciences Centre, GF-543, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9.
Section of Neurology, University of Manitoba, Health Sciences Centre, GF-536, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9.
Mult Scler Relat Disord. 2014 May;3(3):321-5. doi: 10.1016/j.msard.2013.12.007. Epub 2013 Dec 28.
Beta interferons (IFN-β) were the first approved disease modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) and are still the most-widely prescribed medications for this disease. Despite good overall long-term safety data with prolonged use of this group of drugs, they can rarely cause serious and sometimes life threatening adverse effects. In this article we report two cases of thrombotic microangiopathy occurring during prolonged use of IFN-β and review the available literature on this topic.
β干扰素（IFN-β）是首批被批准用于复发缓解型多发性硬化症（RRMS）的疾病修正治疗药物（DMTs），至今仍是治疗该疾病最常用的药物。尽管长期使用这类药物总体安全性良好，但它们仍可能罕见地导致严重甚至危及生命的不良反应。本文报告了两例长期使用IFN-β期间发生血栓性微血管病的病例，并回顾了关于该主题的现有文献。
