Yamasaki Yasushi, Nasu Junichiro, Miura Kou, Kono Yoshiyasu, Kanzaki Hiromitsu, Hori Keisuke, Tanaka Takehiro, Kita Masahide, Tsuzuki Takao, Matsubara Minoru, Kawano Seiji, Kawahara Yoshiro, Tabata Masahiro, Okada Hiroyuki, Yamamoto Kazuhide
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
Intern Med. 2015;54(8):917-20. doi: 10.2169/internalmedicine.54.3469. Epub 2015 Apr 15.
Composite tumors in the stomach composed of adenocarcinoma and neuroendocrine carcinoma are rare. We herein report a case of intramucosal gastric mixed adenoneuroendocrine carcinoma (MANEC) that was treated with endoscopic submucosal dissection (ESD). A 77-year-old man who had previously received ESD for early gastric adenocarcinoma underwent esophagogastroduodenoscopy for screening, which showed a depressed lesion on the lesser curvature of the antrum. The tumor was removed en bloc via ESD and pathologically diagnosed as MANEC. The tumor was located within the mucosal layer, and no lymphovascular invasion was evident. Seven months after the ESD procedure, the patient is currently feeling well without recurrence or metastasis.
胃内由腺癌和神经内分泌癌组成的复合性肿瘤很罕见。我们在此报告一例经内镜黏膜下剥离术（ESD）治疗的胃黏膜内混合性腺神经内分泌癌（MANEC）病例。一名77岁男性，曾因早期胃腺癌接受过ESD治疗，此次因筛查接受食管胃十二指肠镜检查，结果显示胃窦小弯处有一个凹陷性病变。通过ESD将肿瘤完整切除，病理诊断为MANEC。肿瘤位于黏膜层内，未见明显的淋巴管侵犯。ESD术后七个月，患者目前情况良好，无复发或转移。
