Iwamoto Maho, Gotoda Takuji, Noda Yasuhiro, Esaki Mitsuru, Moriyama Mitsuhiko, Yoshida Nao, Takayama Tadatoshi, Kobayashi Hiroko, Masuda Shinobu
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Japan.
Department of Digestive Surgery, Nihon University School of Medicine, Japan.
Intern Med. 2020 May 15;59(10):1271-1276. doi: 10.2169/internalmedicine.3961-19. Epub 2020 Feb 19.
As gastric neuroendocrine carcinoma (NEC) is a rapidly growing cancer, most cases are diagnosed at advanced stages. We herein report a 74-year-old woman with an early-stage gastric NEC whose history included endoscopic submucosal dissection treatment for three early-stage gastric cancer lesions five years prior to the current presentation. We also describe the changes observed over time. An endoscopic examination during follow-up revealed an NEC (measuring 6 mm) in the gastric vestibule, for which distal gastrectomy was performed. Four months before surgery, the carcinoma exhibited specific morphological changes and lymphovascular invasion (despite the tumor being stage 1), suggesting a high-grade NEC.
由于胃神经内分泌癌（NEC）是一种快速发展的癌症，大多数病例在晚期才被诊断出来。我们在此报告一名74岁的早期胃NEC女性患者，其病史包括在本次就诊前五年对三个早期胃癌病变进行了内镜下黏膜下剥离治疗。我们还描述了随时间观察到的变化。随访期间的内镜检查发现胃前庭有一个NEC（直径6毫米），为此进行了远端胃切除术。手术前四个月，尽管肿瘤处于1期，但该癌表现出特定的形态学变化和淋巴管侵犯，提示为高级别NEC。
