Maile Edward John, Tharu Puran Bahadur, Blanchford Hannah L K, Edmiston Rachel, Youngs Robin
Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, USA.
Britain-Nepal Otology Service, Nepalgunj, Nepal.
Trop Med Int Health. 2015 Aug;20(8):1041-7. doi: 10.1111/tmi.12516. Epub 2015 May 28.
Hearing impairment is a significant burden in the developing world. However, no suitable quality of life (QoL) measures exist for use in Nepal. We aimed to amend and translate the Glasgow Health Status Inventory (GHSI), assessing QoL at any given time, and the Glasgow Benefit Inventory (GBI), assessing change in QoL following intervention, into Nepali and to assess the impact of ear disease and effect of surgery on QoL.
The GHSI and GBI were translated into Nepali and independently verified. The GHSI was administered by interview to patients before surgery, and the GBI was administered 6 months after surgery. The Mann-Whitney U-test was used for hypothesis testing.
The GHSI was administered to 242 patients. In total, 205 had chronic suppurative otitis media (CSOM) without cholesteatoma and 37 had cholesteatoma. The mean GHSI score was 47.9. There was no significant difference in GHSI scores between patients with CSOM without cholesteatoma and those with cholesteatoma. The GBI was administered to 161 patients, 73 of whom had also been in the GHSI group. In total, 130 had CSOM without cholesteatoma, 31 had cholesteatoma. The mean GBI score was +38.4 with no significant difference between disease groups.
Ear disease in Nepal is associated with reduced QoL, and surgical intervention is associated with improved QoL. There is no difference in QoL or benefit following surgery for CSOM between patients with or without cholesteatoma. There are few QoL measures suitable for the developing world. It is essential to invest in these measures to guide health interventions.
听力障碍在发展中国家是一项重大负担。然而，尼泊尔没有适用的生活质量（QoL）测量方法。我们旨在将用于评估任意时刻生活质量的格拉斯哥健康状况量表（GHSI）和用于评估干预后生活质量变化的格拉斯哥获益量表（GBI）翻译成尼泊尔语并进行修订，同时评估耳部疾病和手术对生活质量的影响。
将GHSI和GBI翻译成尼泊尔语并独立核实。在手术前通过访谈对患者进行GHSI评估，在手术后6个月进行GBI评估。采用曼-惠特尼U检验进行假设检验。
对242例患者进行了GHSI评估。其中，205例患有无胆脂瘤的慢性化脓性中耳炎（CSOM），37例患有胆脂瘤。GHSI平均得分47.9。无胆脂瘤的CSOM患者与胆脂瘤患者的GHSI得分无显著差异。对161例患者进行了GBI评估，其中73例也在GHSI组中。共有130例无胆脂瘤的CSOM患者，31例胆脂瘤患者。GBI平均得分+38.4，疾病组间无显著差异。
尼泊尔的耳部疾病与生活质量下降相关，手术干预与生活质量改善相关。有无胆脂瘤的CSOM患者术后生活质量或获益无差异。适合发展中国家的生活质量测量方法很少。投资于这些测量方法以指导健康干预至关重要。
