Campanati Anna, Ganzetti Giulia, Giuliodori Katia, Marra Maurizio, Bonfigli Annarita, Testa Roberto, Offidani Annamaria
Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Metabolic Diseases and Diabetology Unit, Italian National Research Center on Aging (INRCA), Ancona, Italy.
Int J Dermatol. 2015 Jul;54(7):839-45. doi: 10.1111/ijd.12706. Epub 2015 Apr 15.
Adipocytokines are bioactive molecules that are deeply involved in the occurrence of atherosclerosis, obesity, and autoimmune inflammatory diseases.
This study was conducted to evaluate the effects of tumor necrosis factor-α (TNF-α) inhibitors on serum levels of adipocytokines in patients with chronic plaque psoriasis.
Serum levels of adiponectin, resistin, visfatin, leptin, TNF-α, and interleukin-6 (IL-6) were evaluated in sera obtained from 47 patients with psoriasis, both at baseline and after they had received TNF-α inhibitors for 24 weeks. Equivalent data were obtained for 39 control subjects matched by age, sex, body mass index, waist : hip ratio, geographical origin, Mediterranean dietary habits, and smoking habits.
At baseline, mean serum levels of TNF-α, IL-6, leptin, resistin, and visfatin were higher in the psoriasis group than in healthy controls; these differences were statistically significant (P < 0.05). Conversely, mean serum levels of adiponectin were significantly lower in patients with psoriasis than in controls (P < 0.0001). Serum levels of adipocytokines did not linearly correlate with anthropometric indices in psoriasis patients (P > 0.05), except in the case of leptin, for which serum levels were related to waist : hip ratio in both men and women (P < 0.05). After 24 weeks of treatment, although serum levels of proinflammatory adipocytokines were decreased, only that of leptin showed a statistically significant reduction (P = 0.0003). Serum levels of adiponectin, an anti-inflammatory adipocytokine, were only mildly increased and persisted at a significantly lower level than in healthy controls (P > 0.005).
Patients with psoriasis show an imbalance between pro- and anti-inflammatory adipocytokines, which is reduced but not normalized after administration of TNF-α inhibitors for 24 weeks. This partial rebalancing seems to be mainly related to a reduction in proinflammatory adipocytokines, rather than an increase in anti-inflammatory adipocytokines.
脂肪细胞因子是一类生物活性分子，与动脉粥样硬化、肥胖症及自身免疫性炎症性疾病的发生密切相关。
本研究旨在评估肿瘤坏死因子-α（TNF-α）抑制剂对慢性斑块状银屑病患者血清脂肪细胞因子水平的影响。
对47例银屑病患者在基线期及接受TNF-α抑制剂治疗24周后的血清进行检测，评估血清脂联素、抵抗素、内脂素、瘦素、TNF-α和白细胞介素-6（IL-6）水平。选取39例在年龄、性别、体重指数、腰臀比、地理来源、地中海饮食习惯及吸烟习惯等方面相匹配的对照者，获取同等数据。
基线期，银屑病组血清TNF-α、IL-6、瘦素、抵抗素和内脂素的平均水平高于健康对照组，差异具有统计学意义（P < 0.05）。相反，银屑病患者血清脂联素的平均水平显著低于对照组（P < 0.0001）。除瘦素外，银屑病患者血清脂肪细胞因子水平与人体测量指标无线性相关性（P > 0.05），瘦素水平在男性和女性中均与腰臀比相关（P < 0.05）。治疗24周后，尽管促炎脂肪细胞因子水平降低，但仅瘦素水平有统计学意义的下降（P = 0.0003）。抗炎脂肪细胞因子脂联素的血清水平仅轻度升高，且仍显著低于健康对照组（P > 0.005）。
银屑病患者促炎和抗炎脂肪细胞因子之间存在失衡，在给予TNF-α抑制剂治疗24周后这种失衡有所减轻但未恢复正常。这种部分重新平衡似乎主要与促炎脂肪细胞因子的减少有关，而非抗炎脂肪细胞因子的增加。
