Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60100 Ancona, Italy.
Dietetic Unit and Clinical Nutrition, United Hospitals of Ancona, 60100 Ancona, Italy.
Nutrients. 2022 Jan 29;14(3):591. doi: 10.3390/nu14030591.
Immune-mediated inflammatory skin diseases are characterized by a complex multifactorial etiology, in which genetic and environmental factors interact both in genesis and development of the disease. Nutrition is a complex and fascinating scenario, whose pivotal role in induction, exacerbation, or amelioration of several human diseases has already been well documented. However, owing to the complexity of immune-mediated skin disease clinical course and breadth and variability of human nutrition, their correlation still remains an open debate in literature. It is therefore important for dermatologists to be aware about the scientific basis linking nutrition to inflammatory skin diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, bullous diseases, vitiligo, and alopecia areata, and whether changes in diet can influence the clinical course of these diseases. The purpose of this narrative review is to address the role of nutrition in immune-mediated inflammatory skin diseases, in light of the most recent and validate knowledge on this topic. Moreover, whether specific dietary modifications could provide meaningful implementation in planning a therapeutic strategy for patients is evaluated, in accordance with regenerative medicine precepts, a healing-oriented medicine that considers the whole person, including all aspects of the lifestyle.
免疫介导的炎症性皮肤疾病的特征是具有复杂的多因素病因，其中遗传和环境因素在疾病的发生和发展中相互作用。营养是一个复杂而迷人的领域，其在诱导、加重或改善几种人类疾病方面的关键作用已经得到充分证实。然而，由于免疫介导的皮肤疾病临床过程的复杂性以及人类营养的广度和可变性，它们之间的相关性在文献中仍然是一个悬而未决的争论。因此，皮肤科医生了解营养与银屑病、特应性皮炎、化脓性汗腺炎、大疱性疾病、白癜风和斑秃等炎症性皮肤疾病之间的科学联系非常重要，饮食的改变是否会影响这些疾病的临床病程。本综述的目的是根据该主题的最新和有效知识，探讨营养在免疫介导的炎症性皮肤疾病中的作用。此外，还根据再生医学原则评估特定的饮食改变是否可以为患者的治疗策略规划提供有意义的实施，再生医学是一种以愈合为导向的医学，它考虑到整个人，包括生活方式的各个方面。
